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Title:
SUBSTITUTED PHENYL DERIVATIVE, ITS PREPARATION, AND REMEDY CONTAINING IT
Document Type and Number:
Japanese Patent JP60142936
Kind Code:
A
Abstract:

NEW MATERIAL:A compound shown by the formula I [R1 is H, alkyl, alkoxy, alkenyl, etc.; R2 is H, or CH3; R3 is hydroxymethyl, carboxyl, carboxymethyl, etc.; R4 is H, halogen, or alkyl; X is CH2O, CH2S, CH2NH, CH2NR5 (R5 is alkyl, or phenyl), CONR5, etc.; n is 0W2; bond containing dotted line is double bond, or single bond], its salt, or its acid addition salt.

EXAMPLE: O-(P-Amylcinnamyl) salicylic acid.

USE: A leulotriene antagonist, phospholipase inhibitor, and 5α-reductase inhibitor.

PREPARATION: For example, a compound shown by the formula II is reacted with a (thiol)phenol derivative or aniline derivative shown by the formula III (Y is O, S, or NR6; R6 is H or R5) in an inert organic solvent at room temperature W80°C, to give a compound shown by the formula I where X is CH2O, CH2S, CH2NG, or CH2NR5.


Inventors:
Arai, Yoshinobu
Toda, Masaaki
Miyamoto, Tsumoru
Application Number:
JP1983000245532
Publication Date:
July 29, 1985
Filing Date:
December 28, 1983
Export Citation:
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Assignee:
ONO PHARMACEUT CO LTD
International Classes:
C07C41/01; A61K31/075; A61K31/085; A61K31/10; A61K31/12; A61K31/135; A61K31/165; A61K31/19; A61K31/195; A61K31/215; A61K31/265; A61P11/00; A61P37/08; A61P43/00; C07C17/16; C07C22/04; C07C33/30; C07C41/00; C07C43/23; C07C45/00; C07C49/245; C07C49/255; C07C49/82; C07C51/00; C07C59/66; C07C65/21; C07C65/28; C07C65/40; C07C67/00; C07C69/003; C07C69/76; C07C209/00; C07C209/10; C07C211/28; C07C211/44; C07C215/76; C07C229/54; C07C231/00; C07C231/02; C07C233/11; C07C233/53; C07C233/55; C07C233/65; C07C233/81; C07C233/88; C07C235/02; C07C235/44; C07C313/00; C07C323/19; C07C323/20; C07C323/62; C07C325/00; C07C327/22; C07C327/26; C07C327/28; C07C327/32; C12N9/99; (IPC1-7): A61K31/075; A61K31/10; A61K31/12; A61K31/135; A61K31/165; A61K31/265; C07C41/01; C07C43/23; C07C49/245; C07C49/255; C07C49/82; C07C59/66; C07C65/21; C07C69/003; C07C87/28; C07C87/29; C07C87/62; C07C103/75; C07C149/36; C07C153/11; C12N9/99