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Title:
SUBSTITUTED PHENYLACETIC ACID AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS5463042
Kind Code:
A
Abstract:

NEW MATERIAL:0-(4-Amino-2,6-dichoroanilino)-phenylacetic acid.

USE: Intermediate for 2-(2,6-dichloroanilino) phenylacetic acid. Sodium salt of the 2-(2,60dichloroanilino) phenyl acetic acid has an anti-inflammatory, analogesic, and antipyretic actions and is a drug known as the general name Dichlorophenac sodium.

PROCESS: 1-(4-Amino-2,6-dichlorophenyl) indolinone of formual II is hydrolyzed with an alkali, e.g. sodium hydroxide, etc. to form an alkali metal salt of 0-(4- amino-2,6-dichloroanilino) phenylacetic acid. The alkali metal salt thus obtained is neutralized with an acid, e.g. hydrochloric acid, etc. to form the objective compound of formula I. The starting compound of formula II is obtained from inexpensive 2,6-dichloro-4-nitroaniline of formula III available as an intermediate for azo disperse dyes.


Inventors:
HIYOUBA ISAO
ANDOU YUMIKO
KAWAKAMI IKUO
SAKOTA RIYOUZOU
NAGANO KAZUO
MORI TOSHIKI
Application Number:
JP1977000128144
Publication Date:
May 21, 1979
Filing Date:
October 27, 1977
Export Citation:
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Assignee:
NISSAN CHEMICAL IND LTD
International Classes:
C07D209/38; C07C67/00; C07C201/00; C07C205/12; C07C209/00; C07C209/10; C07C211/56; C07C227/00; C07C229/42; C07C231/00; C07C233/15; C07C233/56; C07D209/32; (IPC1-7): C07C79/12; C07C87/60; C07C101/447; C07C103/375; C07D209/32



 
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