SUBSTITUTED PHENYLSULFONYL DERIVATIVE, ITS PRODUCTION AND THEREOF
Document Type and Number:
Japanese Patent JP05009170
PURPOSE: To obtain a new compound useful as an excellent antitumor agent.
CONSTITUTION: A compound shown by formula I [X1 and X2 are O, S(O)n ((n) is 0-2), N(R3) (R3 is lower hydrocarbon) or methylene; Y 18 NH-C (=Z)-NH (Z is O or S), N=C(Z')-NH (Z' is halogen, etc.); Ar is phenyl; one of R1 and R2 is H and the other is lower hydrocarbon or R1 and R2 together with C form 3- to 8-membered ring] such as 1-[3,4-(dimethylmethylenedioxy) benzenesulfonyl]-3-(4-chlorophenyl)urea. The compound shown by formula I is obtained by reacting a compound shown by formula II (Y' is N=C=Z, NH2, etc.) with a compound shown by the formula Y"-Ar (Y" is H2N, Z=C=N, etc.) in a solvent (e.g. acetone) in the presence of a base (e.g. NaOH) at 0°C to the boiling temperature of the solvent.
January 19, 1993
April 03, 1991
TAKEDA CHEM IND LTD
A61K31/64; A61P35/00; C07C311/52; C07C311/60; C07C331/28; C07C333/08; C07C335/42; C07D209/08; C07D209/96; C07D235/06; C07D263/56; C07D277/64; C07D307/79; C07D317/62; C07D327/04; C07D333/54; C07D339/06; A61K31/64; A61P35/00; C07C311/00; C07C331/00; C07C333/00; C07C335/00; C07D209/00; C07D235/00; C07D263/00; C07D277/00; C07D307/00; C07D317/00; C07D327/00; C07D333/00; C07D339/00; (IPC1-7): A61K31/64; C07C311/52; C07C311/60; C07C331/28; C07C333/08; C07C335/42; C07D209/08; C07D209/96; C07D235/06; C07D263/56; C07D277/64; C07D307/79; C07D317/62; C07D327/04; C07D333/54; C07D339/06