Title:
置換ピペリジン化合物
Document Type and Number:
Japanese Patent JP2017528464
Kind Code:
A
Abstract:
本開示は、式（Ｉ）：【化１】（式中、Ｒ１、Ｂ、Ｘ、およびＺが、本明細書に記載されるように定義される）で表される置換ピペリジン化合物ならびにその薬学的に許容できる塩および溶媒和物を提供する。本開示は、ＳＭＹＤ３またはＳＭＹＤ２などのＳＭＹＤタンパク質の遮断に反応性の疾患を治療するための式Ｉの化合物の使用にも関する。本開示の化合物は、癌を治療するのに特に有用である。
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Inventors:
Lorna Helen Mitchell
Andrew Simon Bell
Richard Chess Worth
Megan Aline Clunan Foley
Kevin Wayne Kuntz
James Edward John Mills
Michael John Manchhoff
Andrew Simon Bell
Richard Chess Worth
Megan Aline Clunan Foley
Kevin Wayne Kuntz
James Edward John Mills
Michael John Manchhoff
Application Number:
JP2017513207A
Publication Date:
September 28, 2017
Filing Date:
September 09, 2015
Export Citation:
Assignee:
EPIZIM, INCORPORATED
International Classes:
C07D413/12; A61K31/439; A61K31/454; A61K31/497; A61K31/4995; A61K31/5377; A61P35/00; A61P35/02; A61P35/04; A61P43/00; C07D413/14; C07D451/00; C07D471/10; C07D487/08; C12N9/99
Domestic Patent References:
| JP2017528460A | 2017-09-28 | |||
| JP2017526706A | 2017-09-14 | |||
| JP2014505037A | 2014-02-27 | |||
| JPH0327379A | 1991-02-05 |
Foreign References:
| WO2009072643A1 | 2009-06-11 | |||
| WO2008137834A2 | 2008-11-13 |
Other References:
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Attorney, Agent or Firm:
Murai Koji
Horikawa Kaori
Horikawa Kaori