To obtain a substituted piperidinedione derivative which has a structure where the 3-position of the piperidine nucleus is substituted by a benzoyl group, can profitably be synthetized, and is useful for obtaining highly safe herbicides that exhibit sure effects at reduced dosages and have good crop selectivity.
A compound of formula I [R1 to R3 are each nitro, cyano, a halogeno, a 1-6C alkyl or the like; (n) is 0-2; R4, R5 are each H, a halogen, a 1-6C (halo)alkyl or the like; R6, R7 are each a (hydroxy or halogeno) 1-6C alkyl or the like; R8 is H, a 1-6C alkyl, a 2-6C alkenyl or the like; Z is formyl, morpholino or the like]. For example, 3-[2-methyl-3-(3-methylisooxazol-5-yl-4- methylsulfonyl]benzoyl-6,6-dimethylpiperidine-2,4-dione. The compound of formula I is obtained, for example, by reacting a compound of formula II with ArCOQ (Ar is a group of the formula III; Q is a halogen or the like) in the presence of a base to obtain the mixture of a compound of formula IV with a compound of formula V, and then reacting the mixture with a cyano compound in the presence of a mild base.
ADACHI HIROYUKI
KATO MASAHIKO
TAKAHASHI AKIHIRO
FURUGUCHI MASAMI
YAMADA SHIGEO
Next Patent: PRODUCTION OF ORGANIC COMPOUND HAVING NITROXIDE FREE RADICAL