Title:
コレステロールエステル輸送タンパク質活性阻害に有効な置換された多環アリールおよびヘテロアリール第三級ヘテロアルキルアミン
Document Type and Number:
Japanese Patent JP3924124
Kind Code:
B2
Abstract:
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Novel high yield, stereoselective processes for the preparation of the chiral substituted alkanol compounds from chiral and achiral intermediates are described.
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Inventors:
Sikorski, James A
Darley, richard sea
Mishke, Deborah A
Rainhard, Emily Jay
Fobien, Ivette M
Trevson, Michael Bee
Wong, Liguan
Grappler House, Margaret El
Hickory, Brian Es
Mark A, Massa
Norton, Monica Bee
Vernier, William Eff
Barry Elle, Panas
Promo, Michael A
Hamme, Ashton Tea
Spangler, Dale Pee
Rupel, Melvin El
Darley, richard sea
Mishke, Deborah A
Rainhard, Emily Jay
Fobien, Ivette M
Trevson, Michael Bee
Wong, Liguan
Grappler House, Margaret El
Hickory, Brian Es
Mark A, Massa
Norton, Monica Bee
Vernier, William Eff
Barry Elle, Panas
Promo, Michael A
Hamme, Ashton Tea
Spangler, Dale Pee
Rupel, Melvin El
Application Number:
JP2000572183A
Publication Date:
June 06, 2007
Filing Date:
September 23, 1999
Export Citation:
Assignee:
Pharmacia Corporation
International Classes:
C07C217/90; C07D251/46; A61K31/135; A61K31/136; A61K31/137; A61K31/16; A61K31/17; A61K31/196; A61K31/245; A61K31/277; A61K31/33; A61K31/341; A61K31/381; A61K31/395; A61K31/40; A61K31/403; A61K31/404; A61K31/4045; A61K31/42; A61K31/421; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4412; A61K31/4418; A61K31/4453; A61K31/472; A61K31/496; A61K31/505; A61K31/53; A61P3/06; A61P9/10; A61P43/00; B01J31/12; C07B57/00; C07B61/00; C07C213/04; C07C215/08; C07C215/16; C07C215/50; C07C215/68; C07C215/76; C07C217/58; C07C217/84; C07C217/86; C07C217/88; C07C219/34; C07C225/22; C07C229/60; C07C233/65; C07C233/69; C07C233/80; C07C235/38; C07C235/56; C07C237/30; C07C237/38; C07C239/20; C07C255/54; C07C255/55; C07C255/58; C07C275/34; C07C275/40; C07C291/04; C07C311/04; C07C311/08; C07C311/21; C07C311/24; C07C311/60; C07C317/32; C07C317/36; C07C319/20; C07C323/19; C07C323/25; C07C323/31; C07C323/32; C07C323/36; C07C323/37; C07C323/44; C07C323/65; C07D207/323; C07D207/335; C07D209/08; C07D209/32; C07D209/86; C07D213/26; C07D213/30; C07D213/38; C07D213/64; C07D213/643; C07D213/65; C07D213/66; C07D213/85; C07D217/24; C07D225/08; C07D239/26; C07D239/34; C07D251/16; C07D251/42; C07D257/04; C07D263/06; C07D295/135; C07D295/192; C07D307/14; C07D307/42; C07D307/52; C07D309/12; C07D333/20; C07D333/28; C07F7/18; C07D207/32
Domestic Patent References:
| JP11222428A | ||||
| JP2001517655A | ||||
| JP2001513790A | ||||
| JP9255574A | ||||
| JP9059155A | ||||
| JP2002525351A |
Other References:
Tetrahedron,1996年,52(40),p.13017-13026
Attorney, Agent or Firm:
Kazuo Shamoto
Shosuke Imai
Tadashi Masui
Yasushi Kobayashi
Hiroyuki Tomita
Kiyoshi Murakami
Shosuke Imai
Tadashi Masui
Yasushi Kobayashi
Hiroyuki Tomita
Kiyoshi Murakami