Title:
SUBSTITUTED-QUINOXALINE-TYPE PIPERIDINE COMPOUNDS AND USES THEREOF
Document Type and Number:
Japanese Patent JP2014094947
Kind Code:
A
Abstract:
To provide novel compounds which either exhibit agonist activity at the opioid receptor-like (ORL-1) receptor, exhibit partial agonist activity at the ORL-1 receptor, or exhibit antagonist activity at the ORL-1 receptor.
Provided are substituted-quinoxaline-type piperidine compounds represented by the general formula (I) or (II), where Y1 is O or S; Q is fused benzo or 5- or 6-membered heteroaryl; each R2 is independently selected from specific substituents; and a is an integer selected from 0, 1, and 2.
Inventors:
RICHARD R GOEHRING
MATSUMURA AKIRA
SHAO BIN
TAODA YOSHIYUKI
TSUNO MAKI
JOHN WILLIAM FRANK WHITEHEAD
YAO JIANGCHAO
FUCHINO MITSUKI
MATSUMURA AKIRA
SHAO BIN
TAODA YOSHIYUKI
TSUNO MAKI
JOHN WILLIAM FRANK WHITEHEAD
YAO JIANGCHAO
FUCHINO MITSUKI
Application Number:
JP2013263803A
Publication Date:
May 22, 2014
Filing Date:
December 20, 2013
Export Citation:
Assignee:
PURDUE PHARMA LP
SHIONOGI & CO
SHIONOGI & CO
International Classes:
C07D401/04; A61K31/498; A61K31/5377; A61K31/5386; A61P1/10; A61P1/12; A61P1/14; A61P3/04; A61P7/00; A61P9/12; A61P11/14; A61P13/10; A61P25/08; A61P25/16; A61P25/22; A61P25/24; A61P25/28; A61P25/36; A61P43/00; C07D401/14; C07D451/04; C07D487/04; C07D487/08; C07D498/08; C07D519/00
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Kyoei Sugiyama
Yasuhito Suzuki
Norio Omori
Kyoei Sugiyama
Yasuhito Suzuki