Title:
置換チオフェニルアルケニルカルボン酸グアニジドおよびそれらの製造方法
Document Type and Number:
Japanese Patent JP4402747
Kind Code:
B2
Abstract:
Thiophenylalkenylcarboxylic acid guanidide derivatives of formula (I) and their salts are new. at least one of R1-R3 = Op(CH2)sCqF2q+1, R40CO or R31SOk; and the others = H, F, Cl, Br, I, CN, OnaCmaH2ma+1 or OgaCraH2raR10; p = 0 or 1; s = 0-4; q = 1-8; k = 0-2; R40, R31 = 1-8C alkyl, 1-8C perfluoroalkyl, 3-8C cycloalkyl or Ph (optionally substituted by 1-3 F, Cl, CF3, Me or OMe) or NR41R42; R41,R42 = H, 1-4C alkyl or 1-4C perfluoroalkyl; or R41+R42 = (CH2)x in which a CH2 group may be replaced by O, S, NH, NMe or N-benzyl; x = 4 or 5; na = 0 or 1; ma = 0-8; ga = 0 or 1; ra = 0-4; R10 = 3-8C cycloalkyl or Ph (optionally substituted by 1-3 F, Cl, CF3, Me or OMe); R4, R5 = H, F, Cl, Br, I, CN, 1-8C alkyl, 1-8C perfluoroalkyl, 3-8C cycloalkyl or Ph (optionally substituted by 1-3 F, Cl, CF3, Me, OMe or NR14R15); R14, R15 = H, 1-4C alkyl or 1-4C perfluoroalkyl.
Inventors:
Yan-Robert Schievalk
Joachim Brendel
Heinz-Werner Kleman
Hans Johen Lang
Andreas Wueichert
Oud Arbus
Wolfgang Schjorz
Joachim Brendel
Heinz-Werner Kleman
Hans Johen Lang
Andreas Wueichert
Oud Arbus
Wolfgang Schjorz
Application Number:
JP2949597A
Publication Date:
January 20, 2010
Filing Date:
February 14, 1997
Export Citation:
Assignee:
Hoechst Gesellschaft Mito Beschlenktel Haftung
International Classes:
C07D333/24; A61K31/38; C07D333/34; A61K31/381; A61P9/00; A61P9/06; A61P9/08; A61P9/10; A61P35/00; A61P43/00; C07C279/22; C07D333/02; A61P9/12
Domestic Patent References:
| JP7291927A | ||||
| JP8027093A |
Other References:
Chemical Society Reviews,vol.8,No.4(1979)p563-580,表紙
Attorney, Agent or Firm:
Junji Yuda
Shoji Miwa
Noriyuki Takebayashi
Shoji Miwa
Noriyuki Takebayashi