SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVE - CONCERT PHARMACEUTICALS INC

Title:

SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVE

Document Type and Number:

Japanese Patent JP2013100322

Kind Code:

A

Abstract:

To provide a method of treating a disease and a condition that are beneficially treated by administering an α1-GABA-A receptor antagonist and/or α2, α3 and α5 GABA-A receptor agonists.

There are provided substituted triazolo-pyridazines represented by formula 1, derivatives of the same, and pharmaceutically acceptable salts thereof. (In formula, R¹ is CH₃, CDH₂, CD₂H, or CD₃; R² is a t-butyl group having 0-9 deuterium atoms; each Y is independent and is hydrogen or deuterium; and R² has 1-9 deuterium atoms when R¹ is CH₃ and each Y is hydrogen).

Inventors:

HARBESON SCOTT

Application Number:

JP2013004449A

Publication Date:

May 23, 2013

Filing Date:

January 15, 2013

Export Citation:

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Assignee:

CONCERT PHARMACEUTICALS INC

International Classes:

C07D487/04; A61K31/5025; A61K45/00; A61P21/02; A61P25/04; A61P25/06; A61P25/22; A61P25/28; A61P29/00; A61P43/00

Domestic Patent References:

JP2002514169A	2002-05-14
JP2002535407A	2002-10-22
JP2002514169A	2002-05-14
JP2002535407A	2002-10-22

Foreign References:

WO2006061428A2	2006-06-15
WO2006061428A2	2006-06-15

Other References:

JPN6013014075; ＭＣＫＥＲＮＡＮ，Ｒ．Ｍ．　ｅｔ　ａｌ．: 'Ｓｅｄａｔｉｖｅ　ｂｕｔ　ｎｏｔ　ａｎｘｉｏｌｙｔｉｃ　ｐｒｏｐｅｒｔｉｅｓ　ｏｆ　ｂｅｎｚｏｄｉａｚｅｐｉｎｅｓ　ａｒｅ　ｍｅｄｉａｔｅｄ　ｂｙ　ｔｈｅ　ＧＡＢＡ（Ａ）　ｒｅｃｅｐｔｏｒ　ａｌｐｈａ' Ｎａｔ．Ｎｅｕｒｏｓｃｉ．Ｖｏｌ．３，　Ｎｏ．６, 2000, ｐ．５８７-５９２
JPN6013014075; ＭＣＫＥＲＮＡＮ，Ｒ．Ｍ．　ｅｔ　ａｌ．: 'Ｓｅｄａｔｉｖｅ　ｂｕｔ　ｎｏｔ　ａｎｘｉｏｌｙｔｉｃ　ｐｒｏｐｅｒｔｉｅｓ　ｏｆ　ｂｅｎｚｏｄｉａｚｅｐｉｎｅｓ　ａｒｅ　ｍｅｄｉａｔｅｄ　ｂｙ　ｔｈｅ　ＧＡＢＡ（Ａ）　ｒｅｃｅｐｔｏｒ　ａｌｐｈａ' Ｎａｔ．Ｎｅｕｒｏｓｃｉ．Ｖｏｌ．３，　Ｎｏ．６, 2000, ｐ．５８７-５９２

Attorney, Agent or Firm:

Ryoichi Takaoka
Nao Oda

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