Title:
置換1-アミノアルキルラクタム及びムスカリン受容体アンタゴニストとしてのそれらの使用
Document Type and Number:
Japanese Patent JP4071000
Kind Code:
B2
Abstract:
This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR5, and the other substituents are as defined in the specification; and prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
More Like This:
| JP5243455 | New compound |
| WO/2004/081643 | LENSLET ARRAY WITH POLARIZATION CONVERSION |
| WO/2004/080951 | SULFONIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Inventors:
Charles Alois, Dvorak
Lawrence Emerson, Fisher
Green, kina lynn
Harris, Ralph New The Third
Marg, Hans
Prince, Anthony
Repke, David Blues
Russell Stephen, Stabler
Lawrence Emerson, Fisher
Green, kina lynn
Harris, Ralph New The Third
Marg, Hans
Prince, Anthony
Repke, David Blues
Russell Stephen, Stabler
Application Number:
JP2001586270A
Publication Date:
April 02, 2008
Filing Date:
May 16, 2001
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D207/27; A61K31/4015; A61K31/495; A61K31/496; A61K31/535; A61K31/5355; A61K31/55; A61K31/551; A61K31/553; A61P1/04; A61P1/06; A61P1/12; A61P3/00; A61P9/00; A61P11/00; A61P11/06; A61P13/00; A61P13/02; A61P13/06; A61P15/00; A61P21/00; A61P21/02; A61P43/00; C07D211/76; C07D223/10; C07D225/02; C07D239/10; C07D241/08; C07D243/04; C07D243/08; C07D265/10; C07D267/06; C07D267/10; C07D267/22; C07D279/06; C07D401/04; C07D401/06; C07D401/12; C07D403/04; C07D403/06; C07D403/12; C07D405/06; C07D405/12; C07D405/14; C07D409/06; C07D409/12; C07D409/14; C07D411/12; C07D413/06; C07D413/12; C07D413/14; C07D417/04; C07D417/06; C07D417/12; C07D417/14; C07D487/04; C07D513/04; C07D513/14; C07D207/26
Domestic Patent References:
| JP2003516391A | ||||
| JP2003516390A | ||||
| JP9020759A | ||||
| JP5125068A |
Foreign References:
| WO1999043657A1 | ||||
| FR2670785A1 |
Other References:
Glozman, O. M.,Synthesis and cardiovascular properties of 1-dialkylaminoalkyl-4-arylpyrrolidones-2,Khimiko-Farmatsevticheskii Zhurnal,ロシア,1996年,Vol.30,No.4,pp.11-14
武田昌慶,徐脈薬アニリジンとファリパミルの房室伝導に対する作用,信州医学雑誌,1988年,Vol.36,No.1,pp.55-72
Reiffen,M.,Specific bradycardic agents. 1. Chemistry, pharmacology, and structure-activity relationships of sub,J. Med. Chem.,1990年,Vol.33,No.5,pp.1496-1504
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry,1976年,Vol.14B,No.7,pp.528-531
European Journal of Pharmacology,1981年,Vol.72,No.2-3,pp.153-164
武田昌慶,徐脈薬アニリジンとファリパミルの房室伝導に対する作用,信州医学雑誌,1988年,Vol.36,No.1,pp.55-72
Reiffen,M.,Specific bradycardic agents. 1. Chemistry, pharmacology, and structure-activity relationships of sub,J. Med. Chem.,1990年,Vol.33,No.5,pp.1496-1504
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry,1976年,Vol.14B,No.7,pp.528-531
European Journal of Pharmacology,1981年,Vol.72,No.2-3,pp.153-164
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda