Title:
置換1,3-ジオキサンのプロドラッグおよびそれらの使用
Document Type and Number:
Japanese Patent JP2010516702
Kind Code:
A
Abstract:
The present invention relates to prodrugs of compounds containing 1,3-dioxane moiety, pharmaceutical compositions thereof, and the use of the compounds and compositions for the modulation of thromboxane A2 or a peroxisome proliferator-activated receptor. The prodrugs of the compounds, analogs, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions can be used in the treatment and prevention of cancer.
Inventors:
Alberts, Peteris
Sorensen, Alexandra Santana
Sorensen, Alexandra Santana
Application Number:
JP2009546563A
Publication Date:
May 20, 2010
Filing Date:
January 18, 2008
Export Citation:
Assignee:
Evolva SA
International Classes:
C07D319/06; A61K31/357; A61K47/14; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/44; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P7/02; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P15/00; A61P17/00; A61P17/04; A61P17/06; A61P19/10; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P31/00; A61P31/04; A61P31/16; A61P31/18; A61P35/00; A61P35/02; A61P43/00
Domestic Patent References:
| JPS6212772A | 1987-01-21 |
Other References:
JPN6013006992; Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．６， Ｎｏ．３, 1996, ｐ．２７３-２７８
JPN6013006990; Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｙ ａｎｄ Ｐｈａｒｍａｃｏｌｏｇｙ Ｖｏｌ．３８， Ｎｏ．９, 1986, ｐ．７０６-７０８
JPN6013006990; Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｙ ａｎｄ Ｐｈａｒｍａｃｏｌｏｇｙ Ｖｏｌ．３８， Ｎｏ．９, 1986, ｐ．７０６-７０８
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita