Title:
置換1,4-ベンゾジアゼピンおよび癌の処置のためのその使用
Document Type and Number:
Japanese Patent JP4497921
Kind Code:
B2
Abstract:
The present invention is directed to novel 1,4-benzodiazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein: X and Y are independently -C(O)-, -CH2- or -C(S)-; R1, R2, R3, R4, R7, R8, Rb, Rc, Rd and M are defined herein; R5 is hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aralkyl, optionally substituted heteroaralkyl, carboxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, aminocarbonyl, aminocarbonylalkyl, alkylaminocarbonyl or alkylaminocarbonylalkyl; R6 is cycloalkyl, aryl, heteroaryl, cycloalkylalkyl, aralkyl, heteroarylalkyl, or a saturated or partially unsaturated heterocycle, each of which is optionally substituted; R9 is cycloalkyl, aryl, heteroaryl, a saturated or partially unsaturated heterocycle, cycloalkyl(alkyl), aralkyl or heteroarylalkyl, each of which is optionally substituted; and R10 is -(CH2)n-CO2Rb, -(CH2)m-CO2M, -(CH2)i-OH or -(CH2)j-CONRcRd n is 0-8, m is 0-8, i is 1-8 and j is 0-8.
Inventors:
Lou, Tian Bao
La France, Louis Buoy. The Third
Parkes, Daniel Jay.
Milkie Witz, Karen El.
Carbo, Raoul Earl.
Cummings, Maxwell David
Kim, Alexander Jay.
Grassburger, Bruce El.
Carver, Theodore E. Junior
La France, Louis Buoy. The Third
Parkes, Daniel Jay.
Milkie Witz, Karen El.
Carbo, Raoul Earl.
Cummings, Maxwell David
Kim, Alexander Jay.
Grassburger, Bruce El.
Carver, Theodore E. Junior
Application Number:
JP2003543602A
Publication Date:
July 07, 2010
Filing Date:
November 13, 2002
Export Citation:
Assignee:
Ortho-McNeill Pharmacy Incorporated
International Classes:
A61K31/5513; C07D243/14; A61P1/04; A61P3/10; A61P5/00; A61P5/14; A61P7/06; A61P13/12; A61P17/00; A61P17/04; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P25/28; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D401/04; C07D403/04; C07D403/06; C07D403/10; C07D405/04; C07D409/04
Foreign References:
| WO2000064900A1 | ||||
| WO2001055121A1 |
Attorney, Agent or Firm:
Patent business corporation Odashima patent office