Title:
置換3-フェニル-5-アルコキシ-1,3,4-オキサジアゾール-2-オン、これの製造方法および薬剤での使用
Document Type and Number:
Japanese Patent JP4486363
Kind Code:
B2
Abstract:
The invention relates to substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones, of general formula (I), wherein R1 represents C7-C22 alkyl, C2-C4 alkyl that is substituted by C4-C20 alkoxy, C6-C10 aryl, C6-C10 aryloxy or C4-C12-alkoxy-C2-C4-alkoxy, and represents C7-C20 alkenyl, 3 beta -cholestan-3-yl or substituted phenyl; R2, R3, R4 and R5 represent hydrogen, halogen, nitro, C1-C4 alkyl, C1-C9 alkyloxy, trifluoromethyl, trifluoromethoxy or C6-C10-aryl-C1-C4-alkyloxy, C6-C10 aryloxy, C6-C10 aryl, C3-C8 cycloalkyl or O-C3-C8-cycloalkyl, whereby all of these can be substituted. The invention also relates to methods for producing these compounds. The compounds of formula (I) have an inhibiting effect on the pancreatic lipase and can be used as active substances for treating obesity.
Inventors:
Karl Schenafinger
Stephan Petri
Gunther Muller
Armin Bauer
Hubert Otto Hoyer
Stephan Petri
Gunther Muller
Armin Bauer
Hubert Otto Hoyer
Application Number:
JP2003571261A
Publication Date:
June 23, 2010
Filing Date:
February 14, 2003
Export Citation:
Assignee:
Sanofi-Aventis Deutschland Gesellschaft Mitt Beschlenktel Haftung
International Classes:
C07D271/10; A61K31/4245; A61K31/575; A61P3/04; A61P3/10; C07D271/113; C07J43/00
Foreign References:
| WO2001066531A1 | ||||
| WO2001017981A1 |
Attorney, Agent or Firm:
Chika Takagi
Junji Yuda
Shoji Miwa
Junji Yuda
Shoji Miwa