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Title:
治療化合物としての置換カルコン
Document Type and Number:
Japanese Patent JP5235257
Kind Code:
B2
Abstract:
This invention pertains to substituted chalcones, specifically substituted 1-(4-methoxyphenyl)-3-(3,5-dimethoxyphenyl)prop-1-en-3-ones, which have therapeutic application, for example, as potent antiproliferative agents and antiinflammatory agents, and which have the formula (I) wherein: X is -H, -OH, -OC(=O)R3, -OS(=O)2OH, or -OP(=O)(OH)2; Y is -H or a C1-4alkyl group; Z is -H or -OCH3; R1 is -H, a C1-4alkyl group, or C1-4fluoroalkyl group; R2 is -H, a C1-4alkyl group, or C1-4fluoroalkyl group; and, R3 is -H, a C1-6alkyl group, a C3-20 heterocyclyl group, or a C5-20aryl group; and pharmaceutically acceptable salts, esters, and protected forms thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, for both diagnosis and treatment of, for example, proliferative conditions, such as cancer, and inflammatory conditions.

Inventors:
Potter, gerald, andrew
Butler, Paul, Crispin
Wanogo, Erguba
Application Number:
JP2001570595A
Publication Date:
July 10, 2013
Filing Date:
March 26, 2001
Export Citation:
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Assignee:
Spear Therapeutics Limited
International Classes:
A61K49/00; C07C49/84; A61K31/12; A61K31/121; A61K31/15; A61K31/222; A61K31/235; A61P1/04; A61P11/06; A61P17/06; A61P19/02; A61P29/00; A61P35/00; C07C69/017; C07C69/157; C07C251/40; C07C251/48; C07C305/24; C07F9/12; G01N33/574
Domestic Patent References:
JP9501920A
JP60237039A
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka



 
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