置換アミド、その製造法及びBtkインヒビターとしての使用

Japanese Patent JP5529852

B2

The invention relates to compounds of the following Formula I wherein R1, R2, Z, W, and D are defined herein, that inhibit Btk and therefore are useful in the treatment of diseases responsive to inhibition of Btk activity such as cancer. The invention also relates to pharmaceutical compositions comprising at least one compound of Formula I, together with at least one pharmaceutically acceptable vehicle chosen from carriers, adjuvants, and excipients, as well as methods of treating patients suffering from certain diseases responsive to inhibition of Btk activity and/or B-cell activity are described, and methods for determining the presence of Btk in a sample.

Brom Glen, Peter A.
Briteri, David Earl.
Curie, Kevin S.
Li, Sun H.
Klopow, Jeffrey E.
Mitchell, Scott A.
Schmid, Aaron See.
One, Shaochin
Shu, Chiang Chun
Chao, Jeongdong
Titchin, Pavel Yi.

JP2011508632A

June 25, 2014

May 06, 2009

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Jiried Connecticut, Incorporated
Genentech, Incorporated

C07D241/20; C07D401/12; C07D409/12; C07D409/14; C07D413/14; C07D417/12; C07D417/14; C07D487/04; A61K31/4439; A61K31/444; A61K31/496; A61K31/497; A61K31/501; A61K31/519; A61K31/5377; A61K31/551; A61K31/553; A61P19/08; A61P29/00; A61P35/00; A61P35/02; A61P37/06; A61P37/08; A61P43/00

WO2006099075A1
WO2008033858A1
WO2008033857A1
WO2008033834A1
WO2009039397A1

Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Kazumi Nakamura

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