Title:
プロテインキナーゼ阻害剤としての置換3-シアノピリジン
Document Type and Number:
Japanese Patent JP2009539998
Kind Code:
A
Abstract:
The present teachings provide compounds of formula I or a pharmaceutically acceptable salt, hydrate, or ester thereof, wherein: X is selected from a) -NR3-Y-, b) -O-Y-, c) -S(O)m-Y-, d) -S(O)mNR3- Y-, e) -NR3S(O)m-Y-, f) -C(O)NR3-Y-, g) -C(S)NR3-Y-, h) -NR3C(O)- Y-, i) -NR3C(S)-Y-, j) -C(O)O-Y-, k) -OC(O)-Y-, and I) a covalent bond; Y, at each occurrence, independently is selected from a) a divalent C1-10 to alkyl group, b) a divalent C2-10 alkenyl group, c) a divalent C2-10 alkynyl group, d) a divalent C1-10 haloalkyl group, and e) a covalent bond; R1 is selected from a) a C 1-10 alkyl group, b) a C3-14cycloalkyl group, c) a 3-14 membered cycloheteroalkyl group, d) a C8-14 polycyclic aryl group and e) a 5-14 membered heteroaryl group, wherein each group optionally is substituted with 1-4 -Y-R4; R2 is a C6-14 aryl group or a 5-14 membered heteroaryl group, wherein each group optionally is substituted with 1-4 groups independently selected from -Y-R4 Or -O-Y-R4. The present teachings also provide methods of making the compounds of formula I, and methods of treating autoimmune and inflammatory diseases by administering a therapeutically effective amount of a compound or compounds of formula I to a mammal including a human.
Inventors:
Cole, Derek Cecil
Bosserie, Diane Harris
One, canon daniel
Aserin, Magda
Joseph-McCarthy, Diane Marie
Prashad, Amarinato Chestley
Alan Wisner
Dussin, Russell
Woo, bikki
Tsumei, Lawrence Nathan
Niu, Chuan S.
Chen, Joan
Bosserie, Diane Harris
One, canon daniel
Aserin, Magda
Joseph-McCarthy, Diane Marie
Prashad, Amarinato Chestley
Alan Wisner
Dussin, Russell
Woo, bikki
Tsumei, Lawrence Nathan
Niu, Chuan S.
Chen, Joan
Application Number:
JP2009515487A
Publication Date:
November 19, 2009
Filing Date:
June 13, 2007
Export Citation:
Assignee:
Wyeth
International Classes:
C07D213/36; A61K31/433; A61K31/44; A61K31/4425; A61K31/4433; A61K31/455; A61K31/4709; A61K31/4725; A61K31/496; A61K31/506; A61K31/5377; A61K31/541; A61K31/551; A61P1/04; A61P11/06; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P37/06; A61P43/00; C07D213/61; C07D213/84; C07D213/89; C07D401/12; C07D401/14; C07D405/12; C07D405/14; C07D409/14; C07D413/14; C07D417/12; C07D417/14; C07D471/04
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita