置換プロパルギルエトキシアミドヌクレオシド - Applied Biosystems Limited Liability Company

Title:

置換プロパルギルエトキシアミドヌクレオシド

Document Type and Number:

Japanese Patent JP5280879

Kind Code:

B2

Abstract:

Substituted propargylethoxyamido nucleosides are disclosed having the structure wherein X is selected from the group consisting of amino alkanoic acid, alkylamino benzoic acid, alpha -amino acid, and 4-amino-2-butynoic acid. R1 and R2 taken separately are selected from the group consisting of -H, lower alkyl, protecting group, and label; R3 is selected from the group consisting of -H and lower alkyl. B is a 7-deazapurine, purine, or pyrimidine nucleoside base. When B is purine or 7-deazapurine, the sugar moiety is attached at the N9-position of the purine or deazapurine, and when B is pyrimidine, the sugar moiety is attached at the N1-position of the pyrimidine. When B is a purine, the adjacent triple-bonded carbon is attached to the 8-position of the purine, when B is 7-deazapurine, the adjacent triple-bonded carbon is attached to the 7-position of the 7-deazapurine, and when B is pyrimidine, the adjacent triple-bonded carbon is attached to the 5-position of the pyrimidine. W1 is selected from the group consisting of -H and -OH. W2 is -OH or a moiety which renders the nucleoside incapable of forming a phosphodiester bond at the 3'-position. W3 is selected from the group consisting of -PO4, -P2O7, -P3O10, phosphate analog, and -OH. Additionaly, a primer extension method is provided employing the above X-substituted propargylethoxyamido nucleosides, and polynucleotides including the above X-substituted propargylethoxyamido nucleosides is provided.

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Inventors:

Shaheal H. Kang
Stephen M. Menchen
Barnet Bee. Rosen Blam

Application Number:

JP2009026772A

Publication Date:

September 04, 2013

Filing Date:

February 06, 2009

Export Citation:

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Assignee:

Applied Biosystems Limited Liability Company

International Classes:

C07H19/10; C12N15/09; C07H19/04; C07H21/00; C12Q1/68

Domestic Patent References:

JP6509945A

Attorney, Agent or Firm:

Hidesaku Yamamoto
Natsuki Morishita

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