Title:
スルホニル置換六員環誘導体
Document Type and Number:
Japanese Patent JP5377329
Kind Code:
B2
Abstract:
[Problem] To provide a compound that is useful as an agent in the prevention and treatment of circulatory system, nervous system, metabolic, reproductive system, and gastrointestinal diseases. [Means for Resolution] A compound or a pharmaceutically acceptable salt thereof represented by the following Formula (I):
[wherein, Z represents formula (II-1), (II-2), or (II-3),
wherein m and n are 0, 1, or 2,
Y represents CR 3 or N, R 1 represents a C 1-6 alkyl, C 3-8 cycloalkyl, etc., R 2 represents phenyl or a heteroaryl, etc., R 3 and R 4 each independently represent a hydrogen atom, a C 1-6 alkyl, etc., M 1 , M 2 , M 3 , and M 4 each independently represent a hydrogen atom, a C 1-6 alkyl, etc.]
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Inventors:
Go Nagase
Takahide Sasaki
Toshiyuki Takahashi
Takahide Sasaki
Toshiyuki Takahashi
Application Number:
JP2009547047A
Publication Date:
December 25, 2013
Filing Date:
December 16, 2008
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
A61K31/4164; C07C317/44; A61K31/426; A61K31/433; A61K31/44; A61K31/4439; A61K31/444; A61K31/445; A61K31/497; A61K31/505; A61K31/506; A61P1/04; A61P1/16; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P3/12; A61P5/00; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P15/00; A61P17/00; A61P19/02; A61P19/06; A61P25/00; A61P27/02; A61P31/04; A61P31/10; A61P33/00; A61P35/00; A61P43/00; C07D211/54; C07D213/71; C07D213/75; C07D233/84; C07D239/38; C07D277/20; C07D277/36; C07D285/125; C07D401/12; C07D417/12
Domestic Patent References:
| JP2005501120A | 2005-01-13 |
Foreign References:
| WO2009038021A1 | 2009-03-26 | |||
| WO2006131713A1 | 2006-12-14 | |||
| WO2007058942A2 | 2007-05-24 |
Other References:
JPN6009015910; ＨＡＲＶＥＹ， Ｉａｉｎ Ｗ． ｅｔ ａｌ．: 'Ｒａｄｉｃａｌ ｉｎｄｕｃｅｄ ｃｙｃｌｉｚａｔｉｏｎｓ ｏｆ ｕｎｓａｔｕｒａｔｅｄ ａｌｌｙｌｉｃ ｓｕｌｆｏｎｅｓ ｃｏｎｔａｉｎｉｎｇ ａｎ ａｃｔｉｖａｔｉｎｇ ｅｌｅｃｔｒｏｎ ｗｉｔｈｄ' Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ， Ｐｅｒｋｉｎ Ｔｒａｎｓａｃｔｉｏｎｓ １： Ｏｒｇａｎｉｃ ａｎｄ Ｂｉｏ-Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ （１９７２-１９９９ （２）, 1993, １９１-６
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama