Title:
スルホンアミド誘導体またはその薬学的に許容される酸付加塩
Document Type and Number:
Japanese Patent JP6746107
Kind Code:
B2
Abstract:
The purpose of the present invention is to provide a novel low molecular weight compound that exhibits orexin receptor agonist activity and is expected to be useful as an excellent preventative or therapeutic agent for narcolepsy or the like. The present invention provides a sulfonamide derivative represented by general formula (I) that has excellent orexin receptor agonist activity (wherein each symbol has the same definition as that described in the specification) and a pharmaceutically acceptable acid addition salt thereof, as well as an orexin receptor agonist comprising the derivative or the pharmaceutically acceptable acid addition salt thereof.
Inventors:
Masashi Yanagisawa
Hiroshi Nagase
Takeshi Saito
Yoko Irukayama
Hiroshi Nagase
Takeshi Saito
Yoko Irukayama
Application Number:
JP2017500731A
Publication Date:
August 26, 2020
Filing Date:
February 18, 2016
Export Citation:
Assignee:
University of Tsukuba
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
International Classes:
C07C311/29; A61K31/18; A61K31/36; A61K31/4045; A61K31/426; A61K31/431; A61K31/4402; A61K31/4406; A61K31/4439; A61K31/47; A61K31/472; A61K31/498; A61P3/04; A61P3/10; A61P25/20; A61P25/24; A61P31/04; A61P43/00; C07C311/44; C07D209/20; C07D213/32; C07D213/40; C07D215/48; C07D217/26; C07D241/44; C07D277/56; C07D307/56; C07D317/56; C07D417/04
Foreign References:
WO2015088000A1 |
Other References:
NAGAHARA,T. et al,Design and synthesis of non-peptide, selective orexin receptor 2 agonists,JOURNAL OF MEDICINAL CHEMISTRY,2015年,Vol.58,pp.7931-7937
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Junzo Koike
Hirofumi Toma
Atsuko Akai
Tomiya Tozaki
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Junzo Koike
Hirofumi Toma
Atsuko Akai
Tomiya Tozaki