Title:
スルホンアミドならびに薬剤としてのその使用
Document Type and Number:
Japanese Patent JP2010512358
Kind Code:
A
Abstract:
The present invention relates to the use of a sulfonamide compound of formula I:
wherein
R 1 is selected from the group consisting of H, CN, halogen, trifluoromethyl, methyl, ethyl, hydroxyl, methoxyl, ethoxyl, morpholinyl, R 2 is selected from H, phenyl, substituted phenyl, CN, -SO 2 R, wherein R is phenyl or morpholinyl, -NC(O)Me, -NC(O)Et, - CH 2 C(O)OMe, CH 2 C(O)OEt, R 3 is selected from the group consisting of H, NO 2 NH 2 , halogen, -COOMe, -COOEt, RC(O)N-, morpholino, R 4 is selected from the group consisting of H, a branched or unbranched methyl, ethyl, propyl, butyl, pentyl, methoxyl, ethoxyl, propoxyl, butoxyl, a substituted or unsubstituted phenyl, alkynyl, Me 2 SO 2 -, COOR, wherein R is a branched or unbranched methyl, ethyl, propyl, butyl, pentyl, - MeOC(O)-, a substituted or unsubstituted five or six-membered aromatic or non-aromatic heterocyclic system with one , two or three heteroatoms, a heteroaryl system, a condensed benzoheterocyclic system, X is a linker comprising 2 or 3 atoms, selected from the group consisting of -NH-NH-, -NH-NH-CH 2 -, ethynyl, -NH-C(O)-CH 2 -, -NH-NH-SO 2 - -C(O)-NH-CH 2 -, -NH-N=CH-, -NH-N=C(Me)-, a -NH-N=CH- motif being part of a heterocyclic system, preferably a substituted or unsubstituted pyrazole or pyridazine system, and pharmaceutically active salts thereof. Further, the invention relates to the use of these compounds as a medicament, especially for the treatment of cancer.
Inventors:
Gabriel, Garcia
Durham, Pierre
Froche, Barbara
Frank, jaskin skiing
Remylet, Guy
Marty-Ernst, Cornelia
Marzi, Elena
Scapozza, Leonardo
Durham, Pierre
Froche, Barbara
Frank, jaskin skiing
Remylet, Guy
Marty-Ernst, Cornelia
Marzi, Elena
Scapozza, Leonardo
Application Number:
JP2009540652A
Publication Date:
April 22, 2010
Filing Date:
December 11, 2007
Export Citation:
Assignee:
THE GENETICS COMPANY,INC.
International Classes:
C07C311/44; A61K31/415; A61K31/4406; A61K31/5375; A61P35/00; A61P43/00; C07D213/53; C07D213/65; C07D231/12; C07D295/12
Attorney, Agent or Firm:
Noboru Fujimoto
Seiichi Yakumaru
Hiroaki Nakatani
Yuichi Koyama
Seiichi Yakumaru
Hiroaki Nakatani
Yuichi Koyama