Title:
ヒストンデアセチラーゼの新規な阻害剤としてのスルホニル誘導体
Document Type and Number:
Japanese Patent JP4725946
Kind Code:
B2
Abstract:
This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
Inventors:
Van Emmelen, Christoph
Alz, Janine
Bax, Leo Jacobs Joseph
De Winter, Hans Luis Yos
Van Brantz, Sven Franciscus Anna
Beldonck, Marc Gustav Serene
Mail Paul, Leven
Pilate, Isabel Noel Constance
Poncelet, Birjini Sofui
Diatkin, Alexei Borisovic
Vivian Van Heusden, Jimmy Arnold
Alz, Janine
Bax, Leo Jacobs Joseph
De Winter, Hans Luis Yos
Van Brantz, Sven Franciscus Anna
Beldonck, Marc Gustav Serene
Mail Paul, Leven
Pilate, Isabel Noel Constance
Poncelet, Birjini Sofui
Diatkin, Alexei Borisovic
Vivian Van Heusden, Jimmy Arnold
Application Number:
JP2003574641A
Publication Date:
July 13, 2011
Filing Date:
March 11, 2003
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07D207/28; C07D249/12; A61K31/40; A61K31/438; A61K31/4427; A61K31/445; A61K31/4545; A61K31/472; A61K31/495; A61K31/496; A61K31/497; A61K31/501; A61K31/506; A61K31/517; A61K31/52; A61K31/53; A61K31/5377; A61K31/55; A61K31/551; A61K45/00; A61P1/04; A61P3/10; A61P5/00; A61P9/00; A61P9/02; A61P9/08; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P17/04; A61P17/06; A61P17/10; A61P17/14; A61P17/16; A61P19/02; A61P19/06; A61P21/04; A61P25/00; A61P25/16; A61P25/28; A61P27/02; A61P27/06; A61P29/00; A61P31/18; A61P35/00; A61P35/02; A61P37/02; A61P37/04; A61P37/06; A61P37/08; A61P43/00; C07D207/09; C07D207/14; C07D211/26; C07D211/58; C07D213/74; C07D213/78; C07D213/82; C07D215/36; C07D217/02; C07D217/04; C07D233/34; C07D233/64; C07D233/84; C07D233/90; C07D237/24; C07D239/42; C07D239/48; C07D241/04; C07D241/24; C07D241/26; C07D243/08; C07D261/10; C07D295/14; C07D295/155; C07D295/20; C07D295/22; C07D295/26; C07D307/68; C07D307/79; C07D317/58; C07D333/34; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/04; C07D403/12; C07D405/12; C07D405/14; C07D409/04; C07D409/12; C07D409/14; C07D413/02; C07D413/04; C07D413/12; C07D471/10; C07D487/08; C07D513/04; C12Q1/48; C07D
Foreign References:
| WO2001038322A1 | ||||
| WO1998055449A1 |
Other References:
STERNSON,S.M. et al.,Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin,Org. Lett.,2001年,Vol.3, No.26,p.4239-4242
Attorney, Agent or Firm:
Patent business corporation Odashima patent office