Title:
SULFONYLAMINO-SUBSTITUTED BENZOYLGUANIDINES, THEIR PRODUCTION, THEIR USE AS MEDICINE AND DIAGNOSING AUXILIARY, AND MEDICINE CONTAINING THE SAME
Document Type and Number:
Japanese Patent JPH09169721
Kind Code:
A
Abstract:
To obtain a benzoylguanidine useful as a medicine for treating arrhythmia, suitable for intravenous dosage, more improved in water solubility than a well-known compound.
This compound is shown by formula I [R1 is a 1-8C alkyl, etc.; R2 is H, a 1-8C alkyl, etc.; R3 is H, SR25 (R25 is H, a 1-8C alkyl, etc.), etc.; R4 is H, F, etc.; R5 and R6 are each independently H, a 1-4C alkyl, etc.] or its pharmaceutically permissible salt such as 2-methyl-4-isopropyl-5- methylsulfonylaminobenzoylguanidine. The compound of formula I is obtained by reacting a compound of formula II (L is an eliminable group readily removable by a nucleophilic substituent group) with guanidine.
Inventors:
HAINTSUUBUERUNAA KUREEMAN
YOOAHIMU BURENDERU
YANNROOBERUTO SHIYUBUARUKU
ANDOREEASU BUAIHIERUTO
HANSU YOOHEN RANGU
UUDOO ARUBUSU
BUORUFUGANGU SHIYORUTSU
YOOAHIMU BURENDERU
YANNROOBERUTO SHIYUBUARUKU
ANDOREEASU BUAIHIERUTO
HANSU YOOHEN RANGU
UUDOO ARUBUSU
BUORUFUGANGU SHIYORUTSU
Application Number:
JP30137896A
Publication Date:
June 30, 1997
Filing Date:
November 13, 1996
Export Citation:
Assignee:
HOECHST AG
International Classes:
A61K31/18; A61K31/44; A61P1/16; A61P3/08; A61P9/08; A61P9/10; A61P11/00; C07D213/65; A61P13/02; A61P15/00; A61P35/00; A61P43/00; C07C303/34; C07C303/40; C07C307/10; C07C311/08; C07D213/62; (IPC1-7): C07C311/08; A61K31/18; A61K31/44; C07C303/34; C07C303/40; C07C307/10; C07D213/65
Attorney, Agent or Firm:
Chika Takagi (2 outside)
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