SUPER-PARAMAGNETIC IRON-OXIDE NANO-PARTICLE HAVING POSITIVE CHARGE, CONTRAST MEDIUM USING THE SAME AND MANUFACTURING METHOD FOR THE SAME

Title:

SUPER-PARAMAGNETIC IRON-OXIDE NANO-PARTICLE HAVING POSITIVE CHARGE, CONTRAST MEDIUM USING THE SAME AND MANUFACTURING METHOD FOR THE SAME

Document Type and Number:

Japanese Patent JP2012044130

Kind Code:

A

Abstract:

To provide a super-paramagnetic iron-oxide nano-particle having a positive charge, a contrast medium using this and a manufacturing method thereof.

A super-paramagnetic iron-oxide nano-particle having a positive charge according to the present invention comprises: a super-paramagnetic iron-oxide nano-particle; a high polymer layer including a high polymer containing many carboxyl groups with which a surface of the nano-particle is coated; and a positive ionicity substance connected with a surface of the high polymer layer by an amide bond. According to the present invention, the super-paramagnetic iron-oxide nano-particle can be produced easily and with sufficient repeatability so as to have a hydrophilic property and strong positive ionicity. The produced super-paramagnetic iron-oxide nano-particle having the positive charge has high intracellular absorption efficiency and stability, and can be utilized variously as an effective contrast medium using a non-invasive organism image.

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Inventors:

CHOI YON-DOU
KIM HYUN JIN
KIM YUN HEE
KIM DA-HON
KIM IN-HOU

Application Number:

JP2010232806A

Publication Date:

March 01, 2012

Filing Date:

October 15, 2010

Export Citation:

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Assignee:

NAT CANCER CT

International Classes:

H01F1/34; A61B5/055; C01G49/00; C01G49/06; C01G49/08

Domestic Patent References:

JP2008280277A	2008-11-20
JP2007528784A	2007-10-18

Foreign References:

WO2008035759A1

2008-03-27

Other References:

JPN6013030548; Ｃ．　Ｊ．　Ｔａｎ　ｅｔ　ａｌ．: 'Ｐｒｅｐａｒａｔｉｏｎ　ｏｆ　Ｂｏｖｉｎｅ　Ｓｅｒｕｍ　Ａｌｂｕｍｉｎ　Ｓｕｒｆａｃｅ-Ｉｍｐｒｉｎｔｅｄ　Ｓｕｂｍｉｃｒｏｍｅｔｅｒ　Ｐａｒｔｉｃｌｅｓ　ｗｉｔｈ　Ｍａｇｎｅｔｉｃ　Ｓｕｓｃｅｐｔｉ' Ａｎａｌｙｔｉｃａｌ　ＣｈｅｍｉｓｔｒｙＶｏｌ．８０，　Ｎｏ．３, 20080201, ｐ．６８３-６９２
JPN6013030552; Ｖ．　Ｍａｉｌａｎｄｅｒ　ｅｔ　ａｌ．: 'Ｉｎｔｅｒａｃｔｉｏｎ　ｏｆ　Ｎａｎｏｐａｒｔｉｃｌｅｓ　ｗｉｔｈ　Ｃｅｌｌｓ' ＢｉｏｍａｃｒｏｍｏｌｅｃｕｌｅｓＶｏｌ．１０，　Ｎｏ．９, 200909, ｐ．２３７９-２４００

Attorney, Agent or Firm:

Nagoya International Patent Service Corporation

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