Title:
生存運動ニューロン(SMN)遺伝子;脊髄筋萎縮
Document Type and Number:
Japanese Patent JP4723550
Kind Code:
B2
Abstract:
The present invention relates to the discovery of a survival motor-neuron gene or SMN gene which is a chromosome 5-SMA (Spinal Muscular Atrophy) determining gene. The present invention further relates to the nucleotide sequence encoding the SMN gene and corresponding amino acid sequence, a vector containing the gene encoding the SMN protein or a DNA sequence corresponding to the gene and transformant strains containing the SMN gene or a DNA sequence corresponding to the gene. The present invention also relates to means and methods for detecting motor neuron diseases having symptoms of muscular weakness with or without sensory changes such as amytrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), primary lateral sclerosis (PLS) and the like.
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Inventors:
Arnor Munish
Judith Melchi
Judith Melchi
Application Number:
JP2007271610A
Publication Date:
July 13, 2011
Filing Date:
October 18, 2007
Export Citation:
Assignee:
Institut National de la Sainte de la Rercheche Medical
International Classes:
C12N15/09; C07H21/04; C07K14/47; C07K14/475; C07K16/00; C07K16/18; C12N5/10; C12N15/12; C12Q1/68; C12Q1/6883; A61K38/00
Domestic Patent References:
| JP8228785A |
Other References:
Cell,1995年 1月13日,Vol.80,p.155-165
Attorney, Agent or Firm:
Atsushi Aoki
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Masaru Nakajima
Kenji Chatan
Takashi Ishida
Masaya Nishiyama
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Masaru Nakajima
Kenji Chatan
Takashi Ishida
Masaya Nishiyama