SUSTAINED RELEASE DRUG DELIVERY SYSTEM CONTAINING CODRUG

Japanese Patent JP2011052015

A

To provide an improved drug delivery system which has a release speed sustained for a long time at a portion adjacent to an object portion in a body without requiring a complicated manufacturing process.

A sustained release compound contains a polymer matrix and a prodrug having formula A-L-B dispersed in the polymer (A represents a pharmacological active ingredient, L represents a linker to form the prodrug by being bound to A and B, the linker forms A shape showing a therapeutic effect by being cleaved under a physiological condition, and B is bound to A to represent an ingredient to form the prodrug having a lower solubility than the A shape showing the therapeutic effect). The compound has the solubility in water of the A shape showing the therapeutic effect which exceeds 1 mg/ml, and, on the other hand, has the solubility in water of the prodrug which is less than 1 mg/ml.

CHEN JIANBING
ASHTON PAUL
SMITH THOMAS J

JP2010270741A

March 17, 2011

December 03, 2010

Click for automatic bibliography generation  

PSIVIDA INC

A61K47/48; A61F2/84; A61K9/00; A61K9/10; A61K9/22; A61K9/52; A61K31/192; A61K31/196; A61K31/496; A61K31/513; A61K45/00; A61K47/30; A61K47/32; A61K47/34; A61L17/00; A61L29/00; A61L29/16; A61L31/00; A61L31/10; A61L31/16; A61P27/06; A61P29/00; A61P31/00; A61P31/04; A61P31/12; A61P33/10; A61P35/00; A61P37/00; A61P43/00; C08K5/00; C08L101/00; A61K9/70

JPH09509151A	1997-09-16
JPH11500047A	1999-01-06

WO2001001957A1	2001-01-11
WO2000062830A2	2000-10-26

JPN5003017248; ＩＮＧＲＡＭＳ，　Ｄ．Ｒ．　ｅｔ　ａｌ．: ＴＨＥ　ＡＮＮＡＬＳ　ＯＦ　ＯＴＯＬＯＧＹ，　ＲＨＩＮＯＬＯＧＹ，　ＡＮＤ　ＬＡＲＹＮＧＯＬＯＧＹ Ｖｏｌ．　１０９，　Ｎｏ．　４, 200004, ｐ．　４２２-４２４

Motohiro Kurauchi
Axis International Patent Business Corporation

Previous Patent: ヘッドレストステーおよびアクティブヘッドレスト

Next Patent: MECHANISM-BASED TARGETED PANCREATIC β-CELL IMAGING AND THERAPY