Title:
眼疾患治療用及び予防用徐放性医薬組成物
Document Type and Number:
Japanese Patent JP6644433
Kind Code:
B2
Abstract:
The present invention relates to a terpenoid derivative that has the ability to activate the Keap1/Nrf2/ARE signaling pathway and is excellent in anti-inflammatory action and cytoprotective action, and a sustained-release pharmaceutical composition effective for the treatment and prevention of a posterior eye disease caused by oxidative stress, comprising the terpenoid derivative as an active ingredient. The present invention provides a local administration-type sustained-release pharmaceutical composition for the treatment or prevention of a posterior eye disease, comprising the terpenoid derivative of the present invention as an active ingredient, wherein the sustained-release pharmaceutical composition maintains a pharmacological action thereof for 1 week or longer by the sustained release of the terpenoid derivative under physiological conditions and has a base material administrable to the vitreous body and a form administrable to the vitreous body
Inventors:
Yuji Kasuya
Yasuhiro Nakagami
Emiko Hatano
Tatsuya Inoue
Kazuhiro Yoshida
Satoshi Komoriya
Murakami Yoko
Yu Iwasaki
Atsunobu Sakamoto
Kayoko Masuda
Masako Minami
Mayumi Iizuka
Yasunori Ono
Takashi Onuki
Yasuhiro Nakagami
Emiko Hatano
Tatsuya Inoue
Kazuhiro Yoshida
Satoshi Komoriya
Murakami Yoko
Yu Iwasaki
Atsunobu Sakamoto
Kayoko Masuda
Masako Minami
Mayumi Iizuka
Yasunori Ono
Takashi Onuki
Application Number:
JP2016547465A
Publication Date:
February 12, 2020
Filing Date:
September 09, 2015
Export Citation:
Assignee:
Daiichi Sankyo Co., Ltd.
International Classes:
C07J63/00; A61K31/277; A61P1/16; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/02; A61P13/12; A61P21/00; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P27/06; A61P27/12; A61P43/00; C07J71/00; C07J75/00; C12N1/21; C12N9/02; C12N15/53; C12P33/06
Foreign References:
| WO2013188818A1 |
Other References:
Database GenBank [online], Accession No.AEN88225,,, 2014.01.31, [retrieved on 2015 Nov. 12], LIU L., DEF
Database GenBank [online], Accession No.ADE70895,, 2014.01.30, [retrieved on 2015 Nov. 12], EPPINGER M.
Liming LIU,Complete Genome Sequence of the Industrial Strain Bacillus megaterium WSH-002,Journal of Bacteriology,2011年,Vol.193, No.22,Pages 6389-6390,ISSN 0021-8847
Patric CHUA,Draft Genome Sequences of Two Cellulolytic Paenibacillus sp. Strains, MAEPY1 and MAEPY2, from Malays,Genome Announcements,2014年 2月,Vol.2, Issue 1, e00065-14,Pages 1-2,ISSN 2169-8287
Database GenBank [online], Accession No.ADE70895,
Liming LIU,Complete Genome Sequence of the Industrial Strain Bacillus megaterium WSH-002,Journal of Bacteriology,2011年,Vol.193, No.22,Pages 6389-6390,ISSN 0021-8847
Patric CHUA,Draft Genome Sequences of Two Cellulolytic Paenibacillus sp. Strains, MAEPY1 and MAEPY2, from Malays,Genome Announcements,2014年 2月,Vol.2, Issue 1, e00065-14,Pages 1-2,ISSN 2169-8287
Attorney, Agent or Firm:
Kimiki Ishibashi
Noriko Kitano
Toshiyasu Takemoto
Reiko Kanehara
Noriko Kitano
Toshiyasu Takemoto
Reiko Kanehara