Title:
SWINE ERYSIPELOTHRIX RHUSIOPATHIAE FOR EXPRESSING MYCOPLASMA HYOPNEUMONIAE ANTIGEN AND METHOD FOR IMMUNIZATION BY THE BACTERIUM
Document Type and Number:
Japanese Patent JP3793889
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To solve a problem that diseases such as Erysipelothrix rhusiopathiae, Mycoplasma hyopneumoniae, etc., exist in a pig farming industry, various kinds of vaccines are required to healthily breed pigs, however, stress is imposed on pigs by a vaccine injection itself so that in order to alleviate the stress, development of a vaccine capable of decreasing the number of times of vaccine injections and immunizing pigs against several kinds of diseases by one vaccine injection is desired.
SOLUTION: This swine Erysipelothrix rhusiopathiae YS-19 strain expresses a part of P97 adhesin being an adhesive protein on the surface of a microbial cell of detoxicated swine Erysipelothrix rhusiopathiae. This method for immunization comprises preparing a protein and a gene cassette and administering a microbial cell of the YS-19 strain to an animal. This method for immunization comprises preparing a gene cassette from which a part of a gene encoding a surface antigen of swine Erysipelothrix rhusiopathiae and to which a part of P97 adhesin gene of the Mycoplasma hyopneumoniae is inserted, a protein and swine Erysipelothrix rhusiopathiae and administering the protein to an animal.
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Inventors:
Yoshihiro Shimo
Eiji Oishi
Eiji Oishi
Application Number:
JP2000313694A
Publication Date:
July 05, 2006
Filing Date:
October 13, 2000
Export Citation:
Assignee:
Centro Internacional de Agricultura Tropical
Microbial Chemistry Research Institute, Inc.
Yoshihiro Shimo
Microbial Chemistry Research Institute, Inc.
Yoshihiro Shimo
International Classes:
C12N15/09; A61K39/00; A61K39/02; C07K14/30; C07K19/00; C12N1/21; C12R1/01; C12R1/35; (IPC1-7): C12N15/09; A61K39/00; A61K39/02; C07K14/30; C07K19/00; C12N1/21; //(C12N15/09; C12R1:35); (C12N1/21; C12R1:01)
Domestic Patent References:
| JP11151084A |
Other References:
研究ジャーナル, 22 [3] (1999) p.38-42
J. Bacteriol., 179 [4](1997) p.1317-1323
Infect. Immun., 63 [3] (1995) p.1013-1019
Infect. Immun., 67 [4] (1999) p.1646-1651
Vaccine, 12 [7] (1994) p.607-612
J. Bacteriol., 179 [4](1997) p.1317-1323
Infect. Immun., 63 [3] (1995) p.1013-1019
Infect. Immun., 67 [4] (1999) p.1646-1651
Vaccine, 12 [7] (1994) p.607-612
Attorney, Agent or Firm:
Takao Yanagino
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