SYNOSTOSIS PROMOTOR

Japanese Patent JP3789956

B2

PURPOSE: To obtain a synostosis promotor containing a specific active vitamin D and its derivative as active ingredients, promoting bone-repairing step after extension of bone, cut of bone, fracture, etc., and useful for shortage of treating period and prevention and treatment for re-fracture.
CONSTITUTION: This synostosis promotor contains a compound of formula I [R is H, a (substituted)lower alkyl or a (substituted)lower alkyloxy] as an active ingredient. The compound of formula I includes e.g. 2β-(3- hydroxypropyloxy)-1-α-25-dihydroxyvitamine D3 of formula II. The agent is preferably administered as oral agent or by systemic administration of injection, but can be locally injected into a part to be treated. The dose is preferably 0.0001-100μg/kg as the active ingredient.

Yoshimoto Yamamoto
Katsuhiko Sato

JP12589495A

June 28, 2006

April 26, 1995

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Chugai Pharmaceutical Co., Ltd.

A61K31/59; A61P3/02; A61P19/00; A61P43/00; C07C401/00; (IPC1-7): A61K31/59; A61K31/59; A61K31/59

JP6041059A
JP61267549A
JP8508499A

S. Dekel, et al,"The effect of vitamin D and its metabolites on fracture repair in chicks",Clinical Science,1983年,65, 4,p.429-436
J. Blahos et al,"Effect of 1,25-Dihydroxycholecalciferol on Fracture Healing and on General Posttraumatic Skeletal R,Endocrinologia Experimentalis,1989年,23, 4,p.287-294

Kazuo Shamoto
Shosuke Imai
Tadashi Masui
Tadahiko Kurita
Yasushi Kobayashi
Hiroyuki Tomita

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