2-アルキルシステイン、2-(ヒドロキシル化フェニル)-4-アルキルチアゾリン-4-カルボン酸およびそれらの誘導体の合成

Japanese Patent JP2005538950

A

Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves a Michael-type addition of a nucleophile to a dialkyl 2-methylidenylpropan-1,3-dioate and the conversion of a ester moiety into an amino moiety. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, an aryl nitrile or imidate is condensed with cysteine, a 2-alkyl cysteine, or a cysteine ester.

JPH0747578	[Title of Invention] A novel cyclic azoamidine compound and a salt thereof.
JP4560267	Imidazole derivatives and their use as selective agonists for α2B or 2B / 2C adrenergic receptors
JP2011084568	ACETYL 2-HYDROXY-1,3-DIAMINOALKANE

Chanda, Vanu, M.
Shelian, joseph
Korgade, Mukundo, Es.
Jimmy, Raymond, H.
Guruger, Mukund, Kay.
McDonnell, Peter, Dee.
Masker, Sunil, buoy.
Moha Patra, Dedendara, Kay.
Walsten Home-Hogg, Paul

JP2004505355A

December 22, 2005

May 15, 2003

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GENZYME CORPORATION

C07D233/64; A61K31/426; A61P7/02; A61P11/06; A61P29/00; A61P31/12; C07B53/00; C07B55/00; C07B61/00; C07C217/46; C07C227/18; C07C229/06; C07C229/42; C07C249/02; C07C253/00; C07C255/53; C07C255/54; C07C257/08; C07C319/02; C07C319/06; C07C319/12; C07C319/20; C07C323/00; C07C323/25; C07C323/35; C07C323/52; C07C323/56; C07C323/58; C07D213/55; C07D233/16; C07D237/02; C07D277/04; C07D277/08; C07D277/12; C07D277/14; C07D277/18; C07D277/56; C07D303/24; (IPC1-7): C07C319/20; C07C319/02; C07C323/58; C07D233/64; C07D277/12

Yoshinori Hosoda

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