Title:
マイナス型ベータエレメン、マイナス型ベータエレメナル、マイナス型ベータエレメノール、マイナス型ベータフッ化エレメンとそれらの類似体、中間体及び薬剤の合成とその利用法
Document Type and Number:
Japanese Patent JP2008505893
Kind Code:
A
Abstract:
The present invention provides convergent processes for preparing (-)-beta-elemene, (-)-beta-elemenal, (-)-beta-elemenol, and (-)-beta-elemene fluoride and analogues thereof. Also provided are intermediates useful for preparing (-)-beta-elemene. The present invention further provides novel compositions based on analogues of (-)-beta-elemene, (-)-beta-elemenal, (-)-beta-elemenol, (-)-beta-elemene fluoride and methods for the treatment of cancer, such as brain tumor, lung cancer, breast cancer, prostate cancer, ovarian cancer, colorectal cancer, gastric intestional cancer, and stomach cancer. The inventors propose a combination therapy using 1) one or more of the following anti-cancer agents: including, but not limited to, Cisplatin, 5-FU, Taxol, Taxol derivatives, and any anti-cancer agent, and 2) one or more of the following (-)-beta-elemene and its analogs, including (-)-beta-elemene, (-)-beta-elemenal, (-)-beta-elemenol, (-)-beta-elemene fluoride, and their analogs, and (-)-beta-elemene's intermediate in its chemical synthesis, for the treatment of cancer, especially for the treatment of brain tumor, lung cancer, ovarian cancer, bladder cancer, cervical cancer, colon cancer, breast cancer, and prostate cancer.
Inventors:
Juan, Ran
Application Number:
JP2007520297A
Publication Date:
February 28, 2008
Filing Date:
May 02, 2005
Export Citation:
Assignee:
Long Range International USA Limited, Incorporated
International Classes:
C07C49/647; A61K31/015; A61K31/337; A61K31/513; A61K33/24; A61P31/04; A61P31/12; A61P35/00; C07C13/19; C07C35/24; C07C69/75
Foreign References:
| US6464839B1 | 2002-10-15 | |||
| US5665781A | 1997-09-09 | |||
| US6255356B1 | 2001-07-03 | |||
| KR000214802B1 | ||||
| US20020137799A1 | 2002-09-26 |
Attorney, Agent or Firm:
▲吉▼川 俊雄