Title:
SYNTHESIS OF AMIKACIN
Document Type and Number:
Japanese Patent JPS6293297
Kind Code:
A
Abstract:
A novel process for the synthesis of amikacin starting from kanamycin A protected at the positions 3 and 6' is described comprising the reaction of the latter with a salt of a bivalent metal cation selected among zinc, nickel, iron, cobalt, manganese, copper and cadmium in the presence of water as the solvent or co-solvent followed by the in situ reaction of the resulting complex with a reactive derivative of L-amino-2-hydroxybutyric acid, removal of the metal cation of the protecting groups and purification of the thus obtained raw product. the acylation under these conditions is extremely selective.
Inventors:
MANGIA ALBERTO
GIOBBIO VINCENZO
ORNATO GIORGIO
GIOBBIO VINCENZO
ORNATO GIORGIO
Application Number:
JP23939886A
Publication Date:
April 28, 1987
Filing Date:
October 09, 1986
Export Citation:
Assignee:
PIERREL SPA
International Classes:
C07H15/22; C07H15/234; C07H15/236; (IPC1-7): C07H15/234
Attorney, Agent or Firm:
Heikichi Odashima