Title:
新規な誘導システムの合成及び特徴付け、並びに標的細胞への治療対象分子のベクター化
Document Type and Number:
Japanese Patent JP4657721
Kind Code:
B2
Abstract:
A method for preparing a grafted homodetic cyclopeptide forming a framework that defines a grafted upper face and grafted lower face, including synthesizing a linear peptide from modified or unmodified amino acids, some of which carry orthogonal protective groups; intramolecular cyclizing the resulting protected linear peptide; substituting some or all of orthogonal protective groups with a protected precursor; and grafting at least one molecule of interest onto one and/or the other face of the framework via an oxime bond.
Inventors:
Pascal dummy
Mali-Christine Fabro
Didier Botulin
Jean-Luc Cole
Mali-Christine Fabro
Didier Botulin
Jean-Luc Cole
Application Number:
JP2004537232A
Publication Date:
March 23, 2011
Filing Date:
September 19, 2003
Export Citation:
Assignee:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS)
UNIVERSITE JOSEPH FOURIER
INSERM
UNIVERSITE JOSEPH FOURIER
INSERM
International Classes:
C07K1/06; A61K38/00; A61K49/00; A61P35/00; C07K1/107; C07K1/13; C07K4/00; C07K7/64; C07K9/00
Other References:
Tetrahedron Letters,ELSEVIER SCIENCE PUBLISHERS,1995年,Vol.36 No.8,p.1255-1258
Pure & Appl. Chem.,1996年,Vol.68, No.11,p.2153-2162
Angew. Chem. Int. Ed.,1999年,Vol.38, No.5,p.696-699
J. Am. Chem. Soc.,1994年,Vol.116,p.30-33
Angew. Chem. Int. Ed.,1999年,Vol.38, No.4,p.560-562
Tetrahedron Letters,2001年,Vol.42,p.9171-9174
Pure & Appl. Chem.,1996年,Vol.68, No.11,p.2153-2162
Angew. Chem. Int. Ed.,1999年,Vol.38, No.5,p.696-699
J. Am. Chem. Soc.,1994年,Vol.116,p.30-33
Angew. Chem. Int. Ed.,1999年,Vol.38, No.4,p.560-562
Tetrahedron Letters,2001年,Vol.42,p.9171-9174
Attorney, Agent or Firm:
Masago Onishi
Nobuyuki Yamaguchi
Nobuyuki Yamaguchi