Title:
SYNTHESIS OF ISOPENICILLIN DERIVATIVE IN ABSENCE OF LIVE CELL
Document Type and Number:
Japanese Patent JPS5629999
Kind Code:
A
Abstract:
Isopenicillin derivatives having antimicrobial properties and a general formula of: where R, R1, and R2 are hydrogen, methyl, ethyl, propyl, isopropyl, or halogenated methyl, ethyl, propyl or isopropyl radicals and R3 is +TR are produced in a cell-free system using an extract from Cephalosporium acremonium. The starting materials for the synthesis consist of tripeptides composed of unsubstituted or beta -substituted D-valine, unsubstituted or substituted L cysteine, and L- alpha -aminoadipic acid or its analogues. Certain enzymes in the cell-free extract are inactivated so that conversion does not proceed past the isopenicillin stage.
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Inventors:
AANORUDO ERU DEMEIN
TOSHIO KONOMI
JIYATSUKU II BORUDOUIN
TOSHIO KONOMI
JIYATSUKU II BORUDOUIN
Application Number:
JP6413780A
Publication Date:
March 25, 1981
Filing Date:
May 16, 1980
Export Citation:
Assignee:
MASSACHUSETTS INST TECHNOLOGY
International Classes:
C07D499/06; C07D499/48; C12P37/00; (IPC1-7): C12P37/00