SYNTHESIS OF OLIGONUCLEOTIDE

Title:

SYNTHESIS OF OLIGONUCLEOTIDE

Document Type and Number:

Japanese Patent JP2013056939

Kind Code:

A

Abstract:

To provide a method for preparing oligonucleotide that overcomes at least a portion of a fault of the prior art.

This method for preparing the oligonucleotide includes a step (a) of providing a hydroxyl group containing compound having formula (A), a step (b) of reacting the compound with a phosphorylating agent in the presence of an activator (activator I) having formula (I) to prepare a phosphorylated compound; and a step (c) of reacting the phosphorylated compound not isolated with a second compound having formula (A) in the presence of an activator II different from the activator I.

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Inventors:

LANGE MEINOLF
SCHOENBERGER ANDREAS
HOHLFELD ANDREAS
GROESSEL OLAF
KIRCHHOFF CHRISTINE
LINK FRITZ

Application Number:

JP2012278535A

Publication Date:

March 28, 2013

Filing Date:

December 20, 2012

Export Citation:

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Assignee:

GIRINDUS AG

International Classes:

C07H21/04

Domestic Patent References:

JPH1180185A	1999-03-26
JP2004168684A	2004-06-17
JP2004182725A	2004-07-02
JP5435872B2	2014-03-05

Other References:

JPN6012014607; ＢＲＩＬＬ，Ｗ．Ｋ．　ｅｔ　ａｌ: 'Ｓｙｎｔｈｅｓｉｓ　ｏｆ　ｄｅｏｘｙｄｉｎｕｃｌｅｏｓｉｄｅ　ｐｈｏｓｐｈｏｒｏｄｉｔｈｉｏａｔｅｓ' Ｊｏｕｒｎａｌ　ｏｆ　ｔｈｅ　Ａｍｅｒｉｃａｎ　Ｃｈｅｍｉｃａｌ　ＳｏｃｉｅｔｙＶｏｌ．１１３，　Ｎｏ．１０, 1991, ｐｐ．３９７２-３９８０
JPN5010006095; ＨＡＹＡＫＡＷＡ　Ｙ: ＪＯＵＲＮＡＬ　ＯＦ　ＴＨＥ　ＡＭＥＲＩＣＡＮ　ＣＨＥＭＩＣＡＬ　ＳＯＣＩＥＴＹＶ１２３　Ｎ３４, 20010829, Ｐ８１６５-８１７６, ＡＭＥＲＩＣＡＮ　ＣＨＥＭＩＣＡＬ　ＳＯＣＩＥＴＹ
JPN6011064479; Ｔｅｔｒａｈｅｄｒｏｎ　Ｌｅｔｔｅｒｓ４３, 2002, ｐｐ．７９５-７９７

Attorney, Agent or Firm:

Koichi Tsujii
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Shimura

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