SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITOR

Title:

SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITOR

Document Type and Number:

Japanese Patent JP2010095546

Kind Code:

A

Abstract:

To provide a method of enantioselectively synthesizing an amino ceramide-like compound, which is more economical and efficient, and involves fewer steps than known syntheses, and the amino ceramide-like compound obtained by the method.

The compound is represented by the structural formula or a physiologically acceptable salt thereof is provided.

Inventors:

SIEGEL CRAIG
SHAYMAN JAMES A
NELSON CAROL ANNE
HARRIS DAVID J
COPELAND DIANE

Application Number:

JP2010020146A

Publication Date:

April 30, 2010

Filing Date:

February 01, 2010

Export Citation:

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Assignee:

GENZYME CORP
UNIV MICHIGAN

International Classes:

C07D295/12; C07D319/18; A61K31/40; A61K31/4025; A61P1/16; A61P3/00; A61P7/06; A61P17/02; A61P25/28; A61P27/02; A61P35/00; A61P43/00; C07B53/00; C07B61/00; C07D295/18; C07D295/185; C07D498/04

Domestic Patent References:

JPH10338636A	1998-12-22
JP5038582B2	2012-10-03
JPH10338636A	1998-12-22

Foreign References:

WO2001004108A1	2001-01-18
WO2001004108A1	2001-01-18

Other References:

JPN6012043351; Ｊｏｕｒｎａｌ　ｏｆ　ＢｉｏｃｈｅｍｉｓｔｒｙＶｏｌ．１２７，　Ｎｏ．３, 2000, ｐ．４８５-４９１
JPN6012043353; Ｊｏｕｒｎａｌ　ｏｆ　ＢｉｏｃｈｅｍｉｓｔｒｙＶｏ．１１１，　Ｎｏ．２, 1992, ｐ．１９１-１９６
JPN6012043351; Ｊｏｕｒｎａｌ　ｏｆ　ＢｉｏｃｈｅｍｉｓｔｒｙＶｏｌ．１２７，　Ｎｏ．３, 2000, ｐ．４８５-４９１
JPN6012043353; Ｊｏｕｒｎａｌ　ｏｆ　ＢｉｏｃｈｅｍｉｓｔｒｙＶｏ．１１１，　Ｎｏ．２, 1992, ｐ．１９１-１９６

Attorney, Agent or Firm:

Yoshinori Hosoda

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