Title:
合成ヘパリン結合成長因子類似体
Document Type and Number:
Japanese Patent JP5346911
Kind Code:
B2
Abstract:
The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain, and preferably two peptide chains branched from a dipeptide branch moiety composed of two trifunctional amino acid residues, which peptide chain or chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a linker, which may be a hydrophobic linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.
Inventors:
Pena, Lewis, A.
Zamora, Paul, Oh.
Lynn, Sinhwa
Grass, Joan, Dee.
Zamora, Paul, Oh.
Lynn, Sinhwa
Grass, Joan, Dee.
Application Number:
JP2010262096A
Publication Date:
November 20, 2013
Filing Date:
November 25, 2010
Export Citation:
Assignee:
Biosurface Engineering Technologies, Inc.
Broke Haven Science Associate, LRC
Broke Haven Science Associate, LRC
International Classes:
A61L15/16; A61K38/00; A61L17/00; A61L27/00; A61L27/34; A61L31/00; A61L33/10; C07H21/04; C07K14/50; C12N5/071; C07K7/06; C07K7/08; C07K14/475; C07K14/52; C07K19/00
Domestic Patent References:
| JP2006509730A |
Foreign References:
| WO2000018921A1 |
Attorney, Agent or Firm:
Hiroe Associates Patent Office