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Title:
SYNTHETIC INTERMEDIATE FOR VITAMIN D AND STEROIDAL DERIVATIVE AND METHOD OF PRODUCING THE INTERMEDIATE
Document Type and Number:
Japanese Patent JP2002234897
Kind Code:
A
Abstract:

To provide a new compound that bears an ether bond and an epoxy group on the side chain because vitamin D and derivatives thereof have important physiological activity and proliferation inhibitory action, but it has undesirable side effects.

This invention relates to a method of producing the compound having the structure represented by formula I (wherein n is an integer of 1-5; R1 and R2 are each a 1-6C alkyl; W and X are each H or a 1-6C alkyl; Y is O, S or the like; Z represents a compound of formula II or III; R4-R13 are each H or a lower alkyloxy, amino or the like).


Inventors:
Horn, David A.
Kubodera, Noboru
Suzuki, Yasushi
Shimizu, Hitoshi
Application Number:
JP2001000393683
Publication Date:
August 23, 2002
Filing Date:
September 03, 1997
Export Citation:
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Assignee:
TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
CHUGAI PHARMACEUT CO LTD
International Classes:
C07J3/00; C07C41/03; C07C43/184; C07C319/14; C07C401/00; C07D301/28; C07D303/22; C07D303/24; C07J7/00; C07J17/00; C07J51/00; C07C321/16; (IPC1-7): C07J17/00; C07D301/28; C07D303/22
Attorney, Agent or Firm:
社本 一夫 (外4名)