Title:
エクチナサイジン化合物の製造のための合成方法
Document Type and Number:
Japanese Patent JP4942900
Kind Code:
B2
Abstract:
A process step in the manufacture of an ecteinascidin compound comprising deprotecting a compound of formula (A) by removing both protecting groups in a single step to give an alpha aminolactone of formula (35), wherein ProtNH is an amino protecting group and ProtOH is a hydroxy protecting group. Further process steps include oxidizing the alpha aminolactone of formula (35) to a corresponding alpha ketolactone by transamination. Also disclosed are processes for forming the spirotetrahydroisoquinoline compounds Et770 and Et743
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Inventors:
Carmen Cuevas
Marta Perez
Andres Frances
Carolina Fernandez
Jose Luis Cicarlo
Pilar Gallego
Maria Sarsuelo
Ignacio Manzanares
Maria Jesus Martin
Simon Mund
Marta Perez
Andres Frances
Carolina Fernandez
Jose Luis Cicarlo
Pilar Gallego
Maria Sarsuelo
Ignacio Manzanares
Maria Jesus Martin
Simon Mund
Application Number:
JP2001584289A
Publication Date:
May 30, 2012
Filing Date:
May 15, 2001
Export Citation:
Assignee:
Pharma Mar Sociedad Anonima
International Classes:
C07D497/22; A61K35/00; A61P35/00; C07D471/18; C07D491/22; C07D515/22; A61K; C07D
Foreign References:
| WO1998012198A1 | ||||
| WO2000069862A1 |
Other References:
E.J.COREY,J.AM.CHEM.SOC.,1996年,V118,P9202-9203
Attorney, Agent or Firm:
Masatake Shiga
Tadashi Takahashi
Takashi Watanabe
Masakazu Aoyama
Suzuki Mitsuyoshi
Kazuya Nishi
Yasuhiko Murayama
Shinya Mitsuhiro
Tadashi Takahashi
Takashi Watanabe
Masakazu Aoyama
Suzuki Mitsuyoshi
Kazuya Nishi
Yasuhiko Murayama
Shinya Mitsuhiro