SYNTHETIC METHODS OF SERINE, CYSTINE, AND ALANINE REGIO- AND STEREOSELECTIVELY LABELED WITH STABLE ISOTOPE

Title:

SYNTHETIC METHODS OF SERINE, CYSTINE, AND ALANINE REGIO- AND STEREOSELECTIVELY LABELED WITH STABLE ISOTOPE

Document Type and Number:

Japanese Patent JP2007246481

Kind Code:

A

Abstract:

To provide highly versatile synthetic methods capable of synthesizing serine, alanine and cystine (and/or cysteine) regio and stereoselectively labeled with stable isotopes with all kinds of labeling patterns in a high asymmetric yield at a relatively low cost.

The serine labeled with the stable isotope at a desired position can be obtained by using a particular glycine derivative and a formic acid derivative to synthesize a dehydroserine derivative labeled with a stable isotope and subjecting the same to asymmetric reduction. The alanine and the cystine each labeled with the stable isotope at a desired position can be obtained by converting a functional group in a side chain of the serine labeled with the stable isotope prepared by the above process.

Inventors:

KAISO MASATSUNE
TERAUCHI TSUTOMU
OBA MAKOTO
NISHIYAMA KOSABURO

Application Number:

JP2006075192A

Publication Date:

September 27, 2007

Filing Date:

March 17, 2006

Export Citation:

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Assignee:

JAPAN SCIENCE & TECH AGENCY
UNIV TOKAI

International Classes:

C07C227/14; C07C229/08; C07C229/22; C07C319/08; C07C319/14; C07C323/58; C07F7/10; C07B53/00; C07B59/00; C07B61/00

Domestic Patent References:

JPS59163352A	1984-09-14
JPH11315064A	1999-11-16
JPS63258850A	1988-10-26
JP2001122839A	2001-05-08
JPH11322636A	1999-11-24

Foreign References:

WO1999033785A1	1999-07-08
WO2003053910A1	2003-07-03

Attorney, Agent or Firm:

Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama

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