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Title:
SYNTHETIC PEPTIDE CAPABLE OF STIMULATING T-CELLULAR IMMUNITY
Document Type and Number:
Japanese Patent JPH03101697
Kind Code:
A
Abstract:

NEW MATERIAL: A synthetic peptide having an amino acid sequence of the region 1-42, 181-211 or 212-235 of the S1 subunit of pertussis toxin from Bordetella pertussis, the peptide being capable of stimulating T-cellular immunity to pertussis toxin.

USE: Useful as an immunogen-stimulating agent for anti-pertussis, and as acellular anti-pertussis vaccines.

PROCESS: For example, T-cells are cultivated in a medium supplemented with S1 subunit of pertussis toxin. A clone producing an anti-S1 antibody is selected and cultivated to separate an anti-S1 antibody. The reactive portion of the antibody is identified, and a peptide having an amino acid sequence corresponding to the S1 fragment is synthesized by Merriefield solid phase synthesis. Thus, a synthetic peptide containing an amino acid sequence of the amino acid residues of the partial region of the S1 subunit of pertussis toxin can be obtained.


Inventors:
MARIA TEREEZA DE MAJISUTORISU
ANTONETSURA BARUTOROONI
RINO RATSUPUOORI
ARUDO TARIABUE
Application Number:
JP12703490A
Publication Date:
April 26, 1991
Filing Date:
May 18, 1990
Export Citation:
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Assignee:
SCLAVO SPA
International Classes:
A61K39/10; A61K39/39; A61P37/00; C07K7/06; C07K7/08; C07K14/235; C07K19/00; A61K38/00; (IPC1-7): A61K37/02; A61K39/10; A61K39/39; C07K7/06; C07K7/08; C07K7/10; C07K99/00
Attorney, Agent or Firm:
Shusaku Yamamoto (2 outside)