Title:
標的化された核酸編集のための系、方法、及び組成物
Document Type and Number:
Japanese Patent JP7364472
Kind Code:
B2
Abstract:
The invention provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a DNA-targeting Cpf1 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.
Inventors:
Chang Feng
cox david benjamin taits
Gutenberg Jonathan
Abdeye Omar O
Zetsche Bernd
Strecker Jonathan
cox david benjamin taits
Gutenberg Jonathan
Abdeye Omar O
Zetsche Bernd
Strecker Jonathan
Application Number:
JP2019563865A
Publication Date:
October 18, 2023
Filing Date:
May 18, 2018
Export Citation:
Assignee:
The Broad Institute Incorporated
Massachusetts Institute of Technology
President and Fellow's of Harvard College
Massachusetts Institute of Technology
President and Fellow's of Harvard College
International Classes:
C12N15/09; A61K35/12; A61K35/17; A61P7/00; A61P35/00; A61P37/00; A61P43/00; C12N5/10; C12N15/63; C12N15/861; C12N15/864; C12N15/867; C12N15/88
Domestic Patent References:
| JP2017500035A |
Foreign References:
| WO2016205711A1 |
Other References:
Girelli Zubani G. et al.,Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs,J ExpMed,2017年04月03日,Vol. 214(4),pp. 1169-1180
Malzahn A. et al.,Plant genome editing with TALEN and CRISPR,Cell Biosci,2017年04月24日,Vol. 7:21,pp. 1-18
Zheng Y. et al.,DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA,Nucleic Acids Res,2017年01月28日,Vol. 45(6),pp. 3369-3377
Pokharel S. et al.,Matching active site and substrate structures for an RNA editing reaction,J Am Chem Soc,2009年,Vol. 131(33),pp. 11882-11891
Malzahn A. et al.,Plant genome editing with TALEN and CRISPR,Cell Biosci,2017年04月24日,Vol. 7:21,pp. 1-18
Zheng Y. et al.,DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA,Nucleic Acids Res,2017年01月28日,Vol. 45(6),pp. 3369-3377
Pokharel S. et al.,Matching active site and substrate structures for an RNA editing reaction,J Am Chem Soc,2009年,Vol. 131(33),pp. 11882-11891
Attorney, Agent or Firm:
Sykes Patent Attorney Corporation