SYSTEMS AND METHODS FOR NETWORK-BASED BIOLOGICAL ACTIVITY ASSESSMENT

Japanese Patent JP2017073163

A

PROBLEM TO BE SOLVED: To provide systems and methods for network-based biological activity assessment.SOLUTION: Systems and methods are disclosed herein for quantifying the response of a biological system to one or more perturbations based on measured activity data from a subset of entities in the biological system. Based on the activity data and a network model of the biological system that describes the relationships between measured and non-measured entities, activities of entities that are not measured are inferred. The inferred activities are used for deriving a score quantifying the response of the biological system to a perturbation such as a response to a treatment condition. The score may be representative of magnitude and topological distribution of the response of the network to the perturbation.SELECTED DRAWING: None

FLORIAN MARTIN

JP2016241117A

April 13, 2017

December 13, 2016

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PHILIP MORRIS PRODUCTS SA

G16B5/00; G16H50/30

"REVERSE CAUSAL REASONING METHODS - WHITE PAPER", INTERNET CITATION [ONLINE], JPN5014010501, 4 February 2011 (2011-02-04), pages 1 - 26
JULIA HOENG, DRUG DISCOVERY TODAY, vol. Vol.17 No.9-10, JPN5014010504, 1 May 2012 (2012-05-01), pages 413 - 418
"REVERSE CAUSAL REASONING METHODS - WHITE PAPER", INTERNET CITATION [ONLINE], JPN5014010501, 4 February 2011 (2011-02-04), pages 1 - 26
JULIA HOENG, DRUG DISCOVERY TODAY, vol. Vol.17 No.9-10, JPN5014010504, 1 May 2012 (2012-05-01), pages 413 - 418

Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto

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