Title:
T細胞調節方法
Document Type and Number:
Japanese Patent JP2006523226
Kind Code:
A
Abstract:
Regulatory T cells (Treg) limit autoimmunity but can also attenuate the magnitude of anti-pathogen and anti-tumor immunity. Understanding the mechanism of Treg function and therapeutic manipulation of Treg in vivo requires identification of Treg selective receptors. A comparative analysis of gene expression arrays from antigen specific CD4+ T cells differentiating to either an effector/memory or a regulatory phenotype revealed Treg selective expression of LAG-3 (CD223), a CD4-related molecule that binds MHC class II. LAG-3 expression on CD4+ T cells correlates with the cells' in vitro suppressor activity, and ectopic expression of LAG-3 on CD4 T cells confers suppressor activity on the T cells. Antibodies to LAG-3 inhibit suppression both in vitro and in vivo. LAG-3 marks regulatory T cell populations and contributes to their suppressor activity.
Inventors:
Purdor Drew M.
Hang Ching-Thailand
Vignari Dario A.
Workman Greg Jay.
Powell Jonathan
Drake Charles Sea.
Hang Ching-Thailand
Vignari Dario A.
Workman Greg Jay.
Powell Jonathan
Drake Charles Sea.
Application Number:
JP2006508934A
Publication Date:
October 12, 2006
Filing Date:
March 01, 2004
Export Citation:
Assignee:
THE JOHNS HOPKINS UNIVERSITY
International Classes:
C07K14/47; A01N43/04; A61K31/70; A61K35/14; A61K39/00; A61K39/38; A61K39/395; A61K48/00; A61P25/02; A61P31/04; A61P31/18; A61P35/00; A61P37/06; C07K16/00; C07K16/28; C07K19/00; C12N5/0783; C12P21/08; G01N33/15; G01N33/50; G01N33/53; A61K35/12; C12N
Domestic Patent References:
| JP2002505582A | 2002-02-19 | |||
| JP2000508226A | 2000-07-04 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi