Title:
ＴＧＲ５修飾物質およびその使用方法
Document Type and Number:
Japanese Patent JP6861703
Kind Code:
B2
Abstract:
The application relates to compounds of formula (A): or a salt, solvate, ester, tautomer, amino acide conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
Inventors:
Pellicchiari, Roberto
Giello, Antimo
Macchialuro, Antonio
Peron-Shera, Francoise
Seedorf, Claus
Giello, Antimo
Macchialuro, Antonio
Peron-Shera, Francoise
Seedorf, Claus
Application Number:
JP2018517671A
Publication Date:
April 21, 2021
Filing Date:
June 16, 2016
Export Citation:
Assignee:
Intercept Pharmaceuticals, Incorporated
International Classes:
C07J41/00; A61K31/575; A61K31/58; A61P3/00; A61P3/10; A61P43/00; C07J43/00
Domestic Patent References:
| JP2017536379A |
Foreign References:
| WO2008091540A1 | ||||
| WO2016086169A1 | ||||
| WO2016173397A1 |
Other References:
Letters in Drug Design & Discovery,2006年,3,261-267
J. Med. Chem.,2007年,50,4265-4268
J. Med. Chem.,2004年,47,4559-4569
J. Med. Chem.,2007年,50,4265-4268
J. Med. Chem.,2004年,47,4559-4569
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto