Title:
【発明の名称】インダン誘導体及び該化合物を含有するトロンボキサン拮抗剤
Document Type and Number:
Japanese Patent JP2558208
Kind Code:
B2
Abstract:
An indan derivative represented by general formula (1) or a pharmacologically acceptable salt thereof, wherein R<1> represents C1 to C12 alkyl, benzyl, styryl, naphthyl, optionally substituted phenyl or optionally substituted thienyl; R<2> represent carboxyl, C1 to C4 alkoxycarbonyl (2), or (3); Y represents -(CH2)p - (wherein p represents an integer of 0 to 5), - CO-(CH2)q SIMILAR or CH(OH)-(CH2)q SIMILAR (wherein q represents an integer of 1 to 4, and symbol SIMILAR represents a linkage to R<2>), oxymethylene or ethylene; and n represents an integer of 1 to 4. This compound antagonizes the action of thromboxane A2 so potently that it can be utilized to treat or prevent diseases caused by thromboxane A2, such as angiosis, vascular twitch or asthma.
Inventors:
YOSHIDA SEISHI
YAMAJI YOSHIAKI
KURIMOTO TADASHI
SATO RYUICHI
TORITSUKA MOTOKI
YAMAJI YOSHIAKI
KURIMOTO TADASHI
SATO RYUICHI
TORITSUKA MOTOKI
Application Number:
JP50607793A
Publication Date:
November 27, 1996
Filing Date:
September 14, 1992
Export Citation:
Assignee:
ZERIA PHARM CO LTD
International Classes:
A61K31/19; A61K31/195; A61K31/22; A61K31/38; A61K31/50; A61K38/22; A61K38/55; A61P9/00; A61P43/00; C07C311/13; C07C311/17; C07C311/19; C07C311/29; C07C311/42; C07D231/20; C07D237/04; C07D333/34; (IPC1-7): C07C311/13; A61K31/19; A61K31/195; A61K31/22; A61K31/38; A61K31/50; C07C311/17; C07C311/19; C07C311/29; C07D237/04; C07D333/34
Attorney, Agent or Firm:
Miyuki Ariga (3 outside)