Title:
アズレニルニトロンスピントラッピング剤、ならびにその製造方法および使用方法
Document Type and Number:
Japanese Patent JP3887020
Kind Code:
B2
Abstract:
The present invention relates to chromotropic nitrone spin trapping agents, methods of making these agents, compositions comprising same, and methods of their use. In particular, azulenyl nitrones of the present invention are effective agents for trapping free radical species and find use as efficient antioxidants in physicochemical and biological systems. Accordingly, the invention also relates to spin adducts formed from the combination of azulenyl nitrones with free radicals. The compounds of the present invention are readily prepared from available starting materials and find further use in assays and in a number of diagnostic, prophylactic and therapeutic applications, including but not limited to the alleviation, modulation and inhibition of the negative effects of carbon-centered or oxygen-centered radical species and other products of oxidation. Moreover, the combination adducts may be calorimetrically detected and, optionally, isolated and characterized to obtain valuable information (e.g., structural and the like) about the original reactive free radical species.
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Inventors:
Becker David A.
Application Number:
JP51985097A
Publication Date:
February 28, 2007
Filing Date:
November 15, 1996
Export Citation:
Assignee:
Florida International University
International Classes:
C07C291/02; C07D219/10; A61K31/00; A61K31/15; A61K31/16; A61K31/47; A61K31/473; A61P25/00; A61P39/00; A61P39/06; C07C49/21; C07C291/04; C07C309/26; C07C317/30; C07F9/38; C07F9/40
Domestic Patent References:
| JP62132686A | ||||
| JP9077694A | ||||
| JP5505792A | ||||
| JP5506214A | ||||
| JP5221856A | ||||
| JP4169197A |
Foreign References:
| WO1995011227A1 | ||||
| WO1992022290A1 |
Other References:
Liebigs Annalen der Chemie, 1986年,(7), p.1222-1240
Food and Chemical Toxicology, 1989年,27(6), p.393-397
Food and Chemical Toxicology, 1989年,27(6), p.393-397
Attorney, Agent or Firm:
Hatsushi Shimizu