To provide a controlled-release dosage form in relation to the tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms.
The dosage forms that are shaped in a manner that will prevent them from inadvertently passing through the pylorus. A controlled-release oral drug dosage form for releasing a drug into at least a portion of a region defined by the stomach and the upper gastrointestinal tract, the dosage form comprising a solid monolithic matrix with the drug contained therein, the matrix being one that swells upon imbibition of water, the matrix being non-circular in shape and having first and second orthogonal axes of unequal length, the longer such axis having a maximum length of 3.0 cm when the matrix is unswollen, and the shorter such axis achieving a minimum length of 1.2 cm within one hour of immersion of the dosage form in water.
LOUIE-HELM JENNY
JP2003535886A | 2003-12-02 |
WO1998055107A1 | 1998-12-10 | |||
WO1999007342A1 | 1999-02-18 |
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Kazuhiro Nakamura
Masaru Nakajima
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