TARGETED INTEGRATION OF NUCLEIC ACID

Title:

TARGETED INTEGRATION OF NUCLEIC ACID

Document Type and Number:

Japanese Patent JP2022070949

Kind Code:

A

Abstract:

To provide targeted integration (TI) host cells suitable for the expression of recombinant proteins, as well as methods of producing and using the TI host cells.SOLUTION: The present invention pertains to a targeted integration (TI) host cell, comprising an exogenous nucleotide sequence integrated at an integration site within a specific locus of the genome of the host cell, wherein the locus has a specific amino acid sequence.SELECTED DRAWING: Figure 1

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Inventors:

CHI KIN DOMINGOS NG
YONGPING GUO CRAWFORD
AMY SHEN
MEIXIA ZHOU
BRADLEY R SNEDECOR
SHANHRAM MISAGHI
ALBERT ERIC GAO

Application Number:

JP2022019272A

Publication Date:

May 13, 2022

Filing Date:

February 10, 2022

Export Citation:

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Assignee:

GENENTECH INC

International Classes:

C12N15/13; C07K16/00; C07K16/46; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/62; C12N15/63; C12N15/861; C12N15/864; C12N15/867; C12N15/90; C12P21/08

Attorney, Agent or Firm:

Sonoda/Kobayashi Patent Business Corporation

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