Title:
TARGETING ABCB5 FOR CANCER THERAPY
Document Type and Number:
Japanese Patent JP2014133770
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide ABCB5 targeting for cancer therapy.SOLUTION: The present invention is based at least in part on the finding that chemoresistant ABCB5tumor stem cells contribute to the development of cancers such as melanoma and that these cells can be targeted to treat the cancer. ABCB5 targeting may be employed as either a stand-alone therapeutic approach to disseminated disease, or as an adjunctive therapy to sensitize cancer cells to chemotherapeutic agents, especially in those patients with currently refractory metastatic disease. The present invention relates to methods for treating a subject by manipulating ABCB5 on a cell as well as related products. The methods include methods of treating cancer using ABCB5 binding molecules such as antibodies and fragments thereof.
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Inventors:
FRANK MARKUS H
NATASHA Y FRANK
SAYEGH MOHAMED H
NATASHA Y FRANK
SAYEGH MOHAMED H
Application Number:
JP2014090150A
Publication Date:
July 24, 2014
Filing Date:
April 24, 2014
Export Citation:
Assignee:
BRIGHAM & WOMENS HOSPITAL
International Classes:
C07K16/00; A61K31/7105; A61K38/00; A61K39/395; A61K45/00; A61P35/00; C07K16/46; C07K19/00; C12N15/09; C12P21/08
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita
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