Title:
傷ついた組織に対するターゲッティング医薬品剤
Document Type and Number:
Japanese Patent JP4564657
Kind Code:
B2
Abstract:
The present invention provides new compositions and methods to induce therapeutic angiogenesis locally utilizing a collagen binding domain to target an angiogenesis modulating agents. Fusion polypeptides containing a collagen binding domain linked to an angiogenesis modulating agent are provided, as are nucleic acid sequences encoding the fusion polypeptides. Also included are methods for locally altering circulation by administering a fusion polypeptide consisting of a collagen binding domain linked to an angiogenesis modulating agent, or by administering a nucleic acid sequences encoding the fusion polypeptide. Tissue grafts in which isolated tissue is treated with a fusion polypeptide consisting of a collagen binding domain linked to an angiogenesis modulating agent, or with a nucleic acid sequences encoding the fusion polypeptide are also provided, as are methods of making the grafts.
Inventors:
Hall Frederick El
Gordon Elrina Em
Starness Bow A
Anderson W French
Gordon Elrina Em
Starness Bow A
Anderson W French
Application Number:
JP2000562049A
Publication Date:
October 20, 2010
Filing Date:
July 30, 1999
Export Citation:
Assignee:
University of Southern California
International Classes:
C12N15/09; A01K67/027; A61K38/00; A61K38/19; A61K38/27; A61K38/43; A61K39/395; A61K47/48; A61L27/00; A61P1/00; A61P1/04; A61P3/10; A61P9/00; A61P19/00; A61P19/02; A61P29/00; A61P31/00; A61P35/00; C07K7/06; C07K14/515; C07K14/52; C07K14/755; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/62; C12P21/02; C12Q1/02; A61K48/00
Domestic Patent References:
| JP8337596A |
Other References:
Ivan Roitt、外2名,免疫学イラストレイテッド(原書第2版),南江堂,1990年 7月10日,p.323-325
Proceedings of the National Academy of Sciences of the United States of America. 1998 Jun, Vol.95, No.12, p.7018-7023
Annals of the New York Academy of Sciences. 1991, Vol.636, p.233-250
FEBS letters. 1992, Vol.298, No.2-3, p.126-128
Biochemical and molecular medicine. 1996, Vol.58, No.2, p.227-233
Endocrine reviews. 1997, Vol.18, No.1, p.4-25
Human gene therapy. 1997, Vol.8, No.11, p.1385-1394
Proceedings of the National Academy of Sciences of the United States of America. 1998 Jun, Vol.95, No.12, p.7018-7023
Annals of the New York Academy of Sciences. 1991, Vol.636, p.233-250
FEBS letters. 1992, Vol.298, No.2-3, p.126-128
Biochemical and molecular medicine. 1996, Vol.58, No.2, p.227-233
Endocrine reviews. 1997, Vol.18, No.1, p.4-25
Human gene therapy. 1997, Vol.8, No.11, p.1385-1394
Attorney, Agent or Firm:
Sakio Oba
Shinji Kato
Yohei Kobayashi
Shinji Kato
Yohei Kobayashi